Comparison of deaths related to hepatitis C and AIDS in Scotland

Research output: Contribution to journalArticle

Abstract

Summary. In resource-rich countries, the incidence of and mortality from AIDS has fallen dramatically since the introduction of combination antiretroviral therapy. In contrast, developed countries have observed increases in the public health burden associated with the hepatitis C virus (HCV). We compared past and current trends in mortality related to HCV sequelae and HIV/AIDS in Scotland by linking death records with national databases of persons diagnosed with HCV and HIV/AIDS. AIDS-related deaths increased rapidly during the late-1980s to mid-1990s and declined dramatically after 1996. Deaths related to HCV (i.e., viral hepatitis, liver cancer, alcoholic liver disease, or non-alcoholic liver disease) surpassed the number of AIDS-related deaths in 1998 and increased at an average annual rate of 10.5% (95% confidence interval = 7–14%) during 1996–2005. The leading underlying cause of HCV-related deaths was alcoholic liver disease (50% of deaths during 2001–2005). This study highlights the increasing public health burden, vis-à-vis mortality, of HCV, when compared with HIV/AIDS in developed countries. Increased diagnosis and treatment of eligible HCV-infected individuals will be required if we wish to mitigate the future impact of HCV morbidity and mortality.
Original languageEnglish
Pages (from-to)870-874
Number of pages5
JournalJournal of Viral Hepatitis
Volume14
Issue number2
Early online date6 Aug 2007
DOIs
Publication statusPublished - Dec 2007

Fingerprint

Scotland
Hepatitis C
Hepacivirus
Acquired Immunodeficiency Syndrome
Alcoholic Liver Diseases
Mortality
HIV
Liver Neoplasms
Developed Countries
Public Health
Death Certificates
Population Growth
Hepatitis
Liver Diseases
Databases
Confidence Intervals
Morbidity
Incidence

Keywords

  • Hepatitis C
  • AIDS
  • combination antiretroviral therapy
  • Scotland

Cite this

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title = "Comparison of deaths related to hepatitis C and AIDS in Scotland",
abstract = "Summary. In resource-rich countries, the incidence of and mortality from AIDS has fallen dramatically since the introduction of combination antiretroviral therapy. In contrast, developed countries have observed increases in the public health burden associated with the hepatitis C virus (HCV). We compared past and current trends in mortality related to HCV sequelae and HIV/AIDS in Scotland by linking death records with national databases of persons diagnosed with HCV and HIV/AIDS. AIDS-related deaths increased rapidly during the late-1980s to mid-1990s and declined dramatically after 1996. Deaths related to HCV (i.e., viral hepatitis, liver cancer, alcoholic liver disease, or non-alcoholic liver disease) surpassed the number of AIDS-related deaths in 1998 and increased at an average annual rate of 10.5{\%} (95{\%} confidence interval = 7–14{\%}) during 1996–2005. The leading underlying cause of HCV-related deaths was alcoholic liver disease (50{\%} of deaths during 2001–2005). This study highlights the increasing public health burden, vis-{\`a}-vis mortality, of HCV, when compared with HIV/AIDS in developed countries. Increased diagnosis and treatment of eligible HCV-infected individuals will be required if we wish to mitigate the future impact of HCV morbidity and mortality.",
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Comparison of deaths related to hepatitis C and AIDS in Scotland. / Palmateer, N.E.; Hutchinson, S.J.; McLeod, A.; Codere, G.; Goldberg, David.

In: Journal of Viral Hepatitis, Vol. 14, No. 2, 12.2007, p. 870-874.

Research output: Contribution to journalArticle

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AU - Hutchinson, S.J.

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AB - Summary. In resource-rich countries, the incidence of and mortality from AIDS has fallen dramatically since the introduction of combination antiretroviral therapy. In contrast, developed countries have observed increases in the public health burden associated with the hepatitis C virus (HCV). We compared past and current trends in mortality related to HCV sequelae and HIV/AIDS in Scotland by linking death records with national databases of persons diagnosed with HCV and HIV/AIDS. AIDS-related deaths increased rapidly during the late-1980s to mid-1990s and declined dramatically after 1996. Deaths related to HCV (i.e., viral hepatitis, liver cancer, alcoholic liver disease, or non-alcoholic liver disease) surpassed the number of AIDS-related deaths in 1998 and increased at an average annual rate of 10.5% (95% confidence interval = 7–14%) during 1996–2005. The leading underlying cause of HCV-related deaths was alcoholic liver disease (50% of deaths during 2001–2005). This study highlights the increasing public health burden, vis-à-vis mortality, of HCV, when compared with HIV/AIDS in developed countries. Increased diagnosis and treatment of eligible HCV-infected individuals will be required if we wish to mitigate the future impact of HCV morbidity and mortality.

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