Comparison of aminolevulinic acid and its methyl ester mediated photocytotoxicity on human nasopharyngeal carcinoma cells

Christine M.N. Yow; Ricky W.K. Wu; Zheng Huang

doi:10.1142/S1793545812500071

Comparison of aminolevulinic acid and its methyl ester mediated photocytotoxicity on human nasopharyngeal carcinoma cells

Christine M.N. Yow^*, Ricky W.K. Wu, Zheng Huang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Nasopharyngeal carcinoma (NPC) is a prevalent cancer in some areas of southern Asia. To explore the potential of photodynamic therapy (PDT) for the treatment of NPC, a small molecule prodrug 5-aminolevulinic acid (ALA) and its methyl ester (MAL) mediated PDT was studied in vitro. The results showed that human NPC cells were sensitive to both ALA- and MAL-mediated PDT. However, ALA was more effective than MAL, possiblly due to a higher efficiency of ALA on producing endogenous protoporphyrin (PpIX) in NPC cells. Neither ALA nor MAL caused any significant genotoxicity. The ALA-based PDT might be a useful modality in the treatment of NPC.

Original language	English
Article number	1250007
Journal	Journal of Innovative Optical Health Sciences
Volume	5
Issue number	2
DOIs	https://doi.org/10.1142/S1793545812500071
Publication status	Published - 9 May 2012
Externally published	Yes

Keywords

Aminolevulinic acid
methylaminolevulinate
nasopharyngeal carcinoma
photodynamic therapy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Medicine (miscellaneous)
Atomic and Molecular Physics, and Optics
Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1142/S1793545812500071

Cite this

@article{92073755aca64caeb56fb178773416e7,

title = "Comparison of aminolevulinic acid and its methyl ester mediated photocytotoxicity on human nasopharyngeal carcinoma cells",

abstract = "Nasopharyngeal carcinoma (NPC) is a prevalent cancer in some areas of southern Asia. To explore the potential of photodynamic therapy (PDT) for the treatment of NPC, a small molecule prodrug 5-aminolevulinic acid (ALA) and its methyl ester (MAL) mediated PDT was studied in vitro. The results showed that human NPC cells were sensitive to both ALA- and MAL-mediated PDT. However, ALA was more effective than MAL, possiblly due to a higher efficiency of ALA on producing endogenous protoporphyrin (PpIX) in NPC cells. Neither ALA nor MAL caused any significant genotoxicity. The ALA-based PDT might be a useful modality in the treatment of NPC.",

keywords = "Aminolevulinic acid, methylaminolevulinate, nasopharyngeal carcinoma, photodynamic therapy",

author = "Yow, {Christine M.N.} and Wu, {Ricky W.K.} and Zheng Huang",

note = "Funding Information: This project was partially supported by a Hong Kong Polytechnic University grant (GU737).",

year = "2012",

month = may,

day = "9",

doi = "10.1142/S1793545812500071",

language = "English",

volume = "5",

journal = "Journal of Innovative Optical Health Sciences",

issn = "1793-5458",

publisher = "World Scientific",

number = "2",

}

TY - JOUR

T1 - Comparison of aminolevulinic acid and its methyl ester mediated photocytotoxicity on human nasopharyngeal carcinoma cells

AU - Yow, Christine M.N.

AU - Wu, Ricky W.K.

AU - Huang, Zheng

N1 - Funding Information: This project was partially supported by a Hong Kong Polytechnic University grant (GU737).

PY - 2012/5/9

Y1 - 2012/5/9

N2 - Nasopharyngeal carcinoma (NPC) is a prevalent cancer in some areas of southern Asia. To explore the potential of photodynamic therapy (PDT) for the treatment of NPC, a small molecule prodrug 5-aminolevulinic acid (ALA) and its methyl ester (MAL) mediated PDT was studied in vitro. The results showed that human NPC cells were sensitive to both ALA- and MAL-mediated PDT. However, ALA was more effective than MAL, possiblly due to a higher efficiency of ALA on producing endogenous protoporphyrin (PpIX) in NPC cells. Neither ALA nor MAL caused any significant genotoxicity. The ALA-based PDT might be a useful modality in the treatment of NPC.

AB - Nasopharyngeal carcinoma (NPC) is a prevalent cancer in some areas of southern Asia. To explore the potential of photodynamic therapy (PDT) for the treatment of NPC, a small molecule prodrug 5-aminolevulinic acid (ALA) and its methyl ester (MAL) mediated PDT was studied in vitro. The results showed that human NPC cells were sensitive to both ALA- and MAL-mediated PDT. However, ALA was more effective than MAL, possiblly due to a higher efficiency of ALA on producing endogenous protoporphyrin (PpIX) in NPC cells. Neither ALA nor MAL caused any significant genotoxicity. The ALA-based PDT might be a useful modality in the treatment of NPC.

KW - Aminolevulinic acid

KW - methylaminolevulinate

KW - nasopharyngeal carcinoma

KW - photodynamic therapy

U2 - 10.1142/S1793545812500071

DO - 10.1142/S1793545812500071

M3 - Article

AN - SCOPUS:84861954969

SN - 1793-5458

VL - 5

JO - Journal of Innovative Optical Health Sciences

JF - Journal of Innovative Optical Health Sciences

IS - 2

M1 - 1250007

ER -

Comparison of aminolevulinic acid and its methyl ester mediated photocytotoxicity on human nasopharyngeal carcinoma cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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