With over 20 identifiable species of coagulase-negative staphylococci (CNS) recognized only some are associated with human infection. To be pathogenic for man it has been shown that several of these species elaborate a variety of soluble virulence factors, some of which share properties with similar products produced by Staphylococcus aureus including a haemolysin resembling delta-lysin and a DNAase. In addition CNS express specific surface characteristics allowing them to adhere to biopolymers and to form biofilms. In particular CNS produce slime-associated antigen (PS/A) and a capsular polysaccharide adhesins (CPA) which both contribute to surface adhesion and colonization, the first stage of attachment to abiotic or biotic surfaces. Following this stage, proliferation and accumulation as a biofilm occurs and requires the assistance of polysaccharide intracellular adhesin (PIA). Quorum sensing within the developing bacterial population regulates maturation and subsequent disintegration of the biofilm, sometimes involving synthesis of phenol-soluble modulins (PSMs) under the genetic control of agr.Only limited experimental evidence is available showing that CNS express any of these soluble and structural virulence factors in the infection process but it is likely that some are involved.
|Title of host publication||Molecular Medical Microbiology|
|Number of pages||18|
|Publication status||Published - 2015|