Coagulase-negative staphylococci and their role in infection

Curtis G. Gemmell, Susan Lang

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

With over 20 identifiable species of coagulase-negative staphylococci (CNS) recognized only some are associated with human infection. To be pathogenic for man it has been shown that several of these species elaborate a variety of soluble virulence factors, some of which share properties with similar products produced by Staphylococcus aureus including a haemolysin resembling delta-lysin and a DNAase. In addition CNS express specific surface characteristics allowing them to adhere to biopolymers and to form biofilms. In particular CNS produce slime-associated antigen (PS/A) and a capsular polysaccharide adhesins (CPA) which both contribute to surface adhesion and colonization, the first stage of attachment to abiotic or biotic surfaces. Following this stage, proliferation and accumulation as a biofilm occurs and requires the assistance of polysaccharide intracellular adhesin (PIA). Quorum sensing within the developing bacterial population regulates maturation and subsequent disintegration of the biofilm, sometimes involving synthesis of phenol-soluble modulins (PSMs) under the genetic control of agr.
Original languageEnglish
Title of host publicationMolecular Medical Microbiology
PublisherElsevier B.V.
Pages793–810
Number of pages18
Edition2nd
ISBN (Print)9780123971692
DOIs
Publication statusPublished - 2015

Fingerprint

Coagulase
Biofilms
Staphylococcus
Polysaccharides
Infection
Quorum Sensing
Hemolysin Proteins
Biopolymers
Deoxyribonucleases
Virulence Factors
Staphylococcus aureus
Antigens
Population

Keywords

  • bacteriology
  • infection
  • staphylococci
  • pathogenesis

Cite this

Gemmell, C. G., & Lang, S. (2015). Coagulase-negative staphylococci and their role in infection. In Molecular Medical Microbiology (2nd ed., pp. 793–810). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-397169-2.00043-3
Gemmell, Curtis G. ; Lang, Susan. / Coagulase-negative staphylococci and their role in infection. Molecular Medical Microbiology. 2nd. ed. Elsevier B.V., 2015. pp. 793–810
@inbook{71138af9b9954c43ac909909527be8b7,
title = "Coagulase-negative staphylococci and their role in infection",
abstract = "With over 20 identifiable species of coagulase-negative staphylococci (CNS) recognized only some are associated with human infection. To be pathogenic for man it has been shown that several of these species elaborate a variety of soluble virulence factors, some of which share properties with similar products produced by Staphylococcus aureus including a haemolysin resembling delta-lysin and a DNAase. In addition CNS express specific surface characteristics allowing them to adhere to biopolymers and to form biofilms. In particular CNS produce slime-associated antigen (PS/A) and a capsular polysaccharide adhesins (CPA) which both contribute to surface adhesion and colonization, the first stage of attachment to abiotic or biotic surfaces. Following this stage, proliferation and accumulation as a biofilm occurs and requires the assistance of polysaccharide intracellular adhesin (PIA). Quorum sensing within the developing bacterial population regulates maturation and subsequent disintegration of the biofilm, sometimes involving synthesis of phenol-soluble modulins (PSMs) under the genetic control of agr.",
keywords = "bacteriology, infection, staphylococci, pathogenesis",
author = "Gemmell, {Curtis G.} and Susan Lang",
note = "Chapter appears in volume 2 of the book",
year = "2015",
doi = "10.1016/B978-0-12-397169-2.00043-3",
language = "English",
isbn = "9780123971692",
pages = "793–810",
booktitle = "Molecular Medical Microbiology",
publisher = "Elsevier B.V.",
edition = "2nd",

}

Gemmell, CG & Lang, S 2015, Coagulase-negative staphylococci and their role in infection. in Molecular Medical Microbiology. 2nd edn, Elsevier B.V., pp. 793–810. https://doi.org/10.1016/B978-0-12-397169-2.00043-3

Coagulase-negative staphylococci and their role in infection. / Gemmell, Curtis G.; Lang, Susan.

Molecular Medical Microbiology. 2nd. ed. Elsevier B.V., 2015. p. 793–810.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

TY - CHAP

T1 - Coagulase-negative staphylococci and their role in infection

AU - Gemmell, Curtis G.

AU - Lang, Susan

N1 - Chapter appears in volume 2 of the book

PY - 2015

Y1 - 2015

N2 - With over 20 identifiable species of coagulase-negative staphylococci (CNS) recognized only some are associated with human infection. To be pathogenic for man it has been shown that several of these species elaborate a variety of soluble virulence factors, some of which share properties with similar products produced by Staphylococcus aureus including a haemolysin resembling delta-lysin and a DNAase. In addition CNS express specific surface characteristics allowing them to adhere to biopolymers and to form biofilms. In particular CNS produce slime-associated antigen (PS/A) and a capsular polysaccharide adhesins (CPA) which both contribute to surface adhesion and colonization, the first stage of attachment to abiotic or biotic surfaces. Following this stage, proliferation and accumulation as a biofilm occurs and requires the assistance of polysaccharide intracellular adhesin (PIA). Quorum sensing within the developing bacterial population regulates maturation and subsequent disintegration of the biofilm, sometimes involving synthesis of phenol-soluble modulins (PSMs) under the genetic control of agr.

AB - With over 20 identifiable species of coagulase-negative staphylococci (CNS) recognized only some are associated with human infection. To be pathogenic for man it has been shown that several of these species elaborate a variety of soluble virulence factors, some of which share properties with similar products produced by Staphylococcus aureus including a haemolysin resembling delta-lysin and a DNAase. In addition CNS express specific surface characteristics allowing them to adhere to biopolymers and to form biofilms. In particular CNS produce slime-associated antigen (PS/A) and a capsular polysaccharide adhesins (CPA) which both contribute to surface adhesion and colonization, the first stage of attachment to abiotic or biotic surfaces. Following this stage, proliferation and accumulation as a biofilm occurs and requires the assistance of polysaccharide intracellular adhesin (PIA). Quorum sensing within the developing bacterial population regulates maturation and subsequent disintegration of the biofilm, sometimes involving synthesis of phenol-soluble modulins (PSMs) under the genetic control of agr.

KW - bacteriology

KW - infection

KW - staphylococci

KW - pathogenesis

U2 - 10.1016/B978-0-12-397169-2.00043-3

DO - 10.1016/B978-0-12-397169-2.00043-3

M3 - Chapter (peer-reviewed)

SN - 9780123971692

SP - 793

EP - 810

BT - Molecular Medical Microbiology

PB - Elsevier B.V.

ER -

Gemmell CG, Lang S. Coagulase-negative staphylococci and their role in infection. In Molecular Medical Microbiology. 2nd ed. Elsevier B.V. 2015. p. 793–810 https://doi.org/10.1016/B978-0-12-397169-2.00043-3