Circulating cytokines after hip and knee arthroplasty: a preliminary study

Kalpesh Shah, Aslam Mohammed, Sanjeev Patil, Angus McFadyen, R. M. Meek

    Research output: Contribution to journalArticle

    Abstract

    Several studies show cytokine concentrations in the peripheral blood are associated with inflammatory activity and surgical trauma. Cytokine concentrations have more rapid increase and quicker return to normal values than either C-reactive protein or erythrocyte sedimentation rate - a matter of hours rather than weeks; some studies suggest they are better predictors of postoperative infection than C-reactive protein and erythrocyte sedimentation rate. Threshold levels of interleukin-6 after joint arthroplasty have been determined, but levels of other potentially useful cytokines (tumor necrosis factor-alpha, interleukin-8, interleukin-10, etc) are not known. We measured the serum levels of 25 different cytokines before and after hip and knee arthroplasties and identified those associated with surgical trauma.

    Original languageEnglish
    Pages (from-to)946-951
    Number of pages6
    JournalClinical Orthopaedics and Related Research
    Volume467
    Issue number4
    DOIs
    Publication statusPublished - 1 Apr 2009

    Keywords

    • cytokines
    • arthroplasty
    • surgery

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