Abstract
OBJECTIVE: Intergenerational data on mother-offspring pairs were utilized in an instrumental variable analysis to examine the longitudinal association between BMI and sedentary behavior.
METHODS: The sample included 3,864 mother-offspring pairs from the 1970 British Cohort Study. Height and weight were recorded in mothers (age 31 [5.4] years) and offspring (age 10 years) and repeated in offspring during adulthood. Offspring provided objective data on sedentary behavior (7-day thigh-worn activPAL) in adulthood at age 46 to 47 years.
RESULTS: Maternal BMI, the instrumental variable, was associated with offspring BMI at age 10 (change per kg/m2 , β = 0.11; 95% CI: 0.09 to 0.12), satisfying a key assumption of instrumental variable analyses. Offspring (change per kg/m2 , β = 0.010; 95% CI: -0.02 to 0.03 h/d) and maternal BMI (β = 0.017; 95% CI: 0.001 to 0.03 h/d) was related to offspring sedentary time, suggestive of a causal impact of BMI on sedentary behavior (two-stage least squares analysis, β = 0.18 [SE 0.08], P = 0.015). For moderate-vigorous physical activity, there were associations with offspring BMI (β = -0.010; 95% CI: -0.017 to -0.004) and maternal BMI (β = -0.007; 95% CI: -0.010 to -0.003), with evidence for causality (two-stage least squares analysis, β = -0.060 [SE 0.02], P = 0.001).
CONCLUSIONS: There is strong evidence for a causal pathway linking childhood obesity to greater sedentary behavior.
| Original language | English |
|---|---|
| Pages (from-to) | 220-225 |
| Number of pages | 6 |
| Journal | Obesity |
| Volume | 29 |
| Issue number | 1 |
| Early online date | 1 Nov 2020 |
| DOIs | |
| Publication status | Published - Jan 2021 |
Keywords
- adult
- Body Mass Index
- body weight
- causality
- child
- cohort studies
- England
- female
- humans
- male
- middle aged
- mothers
- pediatric obesity
- Scotland
- sedentary behavior
- Wales
ASJC Scopus subject areas
- Endocrinology
- Nutrition and Dietetics
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
Documents and Links
- Hamer, M. et al (2021) Childhood obesity and device-measured sedentary behavior an instrumental variable analysis of 3,864 mother-offspring pairs
© 2020 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS). This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.