Abstract
OBJECTIVE: Intergenerational data on mother-offspring pairs were utilized in an instrumental variable analysis to examine the longitudinal association between BMI and sedentary behavior.
METHODS: The sample included 3,864 mother-offspring pairs from the 1970 British Cohort Study. Height and weight were recorded in mothers (age 31 [5.4] years) and offspring (age 10 years) and repeated in offspring during adulthood. Offspring provided objective data on sedentary behavior (7-day thigh-worn activPAL) in adulthood at age 46 to 47 years.
RESULTS: Maternal BMI, the instrumental variable, was associated with offspring BMI at age 10 (change per kg/m2 , β = 0.11; 95% CI: 0.09 to 0.12), satisfying a key assumption of instrumental variable analyses. Offspring (change per kg/m2 , β = 0.010; 95% CI: -0.02 to 0.03 h/d) and maternal BMI (β = 0.017; 95% CI: 0.001 to 0.03 h/d) was related to offspring sedentary time, suggestive of a causal impact of BMI on sedentary behavior (two-stage least squares analysis, β = 0.18 [SE 0.08], P = 0.015). For moderate-vigorous physical activity, there were associations with offspring BMI (β = -0.010; 95% CI: -0.017 to -0.004) and maternal BMI (β = -0.007; 95% CI: -0.010 to -0.003), with evidence for causality (two-stage least squares analysis, β = -0.060 [SE 0.02], P = 0.001).
CONCLUSIONS: There is strong evidence for a causal pathway linking childhood obesity to greater sedentary behavior.
Original language | English |
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Pages (from-to) | 220-225 |
Number of pages | 6 |
Journal | Obesity |
Volume | 29 |
Issue number | 1 |
Early online date | 1 Nov 2020 |
DOIs | |
Publication status | Published - Jan 2021 |
Keywords
- adult
- Body Mass Index
- body weight
- causality
- child
- cohort studies
- England
- female
- humans
- male
- middle aged
- mothers
- pediatric obesity
- Scotland
- sedentary behavior
- Wales
ASJC Scopus subject areas
- Endocrinology
- Nutrition and Dietetics
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism