Changes in corneal sensitivity and tear physiology after phacoemulsification

Khanal Santosh, Alan Tomlinson, Leonard Esakowitz, Priya Bhatt, David Jones, Shahriar Nabili, Subhanjan Mukerji

Research output: Contribution to journalArticlepeer-review

103 Citations (Scopus)


This study aimed to identify any changes in corneal sensitivity and tear physiology after phacoemulsification and to evaluate the effectiveness of the use of ophthalmic lubricants. The design of the study was longitudinal, parallel, randomised and double masked. Eighteen patients (average age 70.83 ± 10.66 years, 7 males and 11 females) undergoing phacoemulsification were recruited and divided into three groups of six. In addition to the prednisolone acetate 1% and chloramphenicol 0.5% routinely given to patients postoperatively, the first two groups were given a tear lubricant (Refresh® Soothe and Protect™, Allergan Inc., Irvine, CA, USA) and saline (Chauvin Pharmaceuticals Ltd, Essex, UK), respectively, and the third was a control group and did not receive any additional eye drops. Tear production, evaporation, lipid layer interferometry and osmolarity along with corneal sensitivity were measured before and 3 days, 2 weeks, 1 month and 3 months after the surgery.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalOphthalmic and Physiological Optics
Issue number2
Publication statusPublished - 1 Mar 2008


  • cornea
  • tear physiology
  • vision sciences


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