Central corneal thickness (CCT) and IOP measures in human corneas with endothelial guttata: an observational quality control study

The aim of the present study was to assess central corneal thickness (CCT) and intraocular pressure (IOP) in eyes where the corneas were affected by different degrees of severity of endothelial pseudo-guttata or guttata. In a prospective, case series observational study, non-contact tonometry and non-contact specular microscopy (NCSM) with pachymetry for central corneal thickness measures were undertaken as routine procedures on predominantly older patients without a history of corneal problems or contact lens wear. For those showing any signs of corneal endothelial abnormalities, images of the central cornea endothelium were further processed to measure the area (as a percentage) occupied by the guttata.