Central and local administration of Gingko biloba extract EGb 761® inhibits thermal hyperalgesia and inflammation in the rat carrageenan model

Laura Biddlestone; Michelle Goldie; Sharron Dolan

Central and local administration of Gingko biloba extract EGb 761® inhibits thermal hyperalgesia and inflammation in the rat carrageenan model

Laura Biddlestone, Michelle Goldie, Sharron Dolan

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Oral administration of the standardized Ginkgo biloba extract EGb 761® has been shown to inhibit thermal hyperalgesia in rodent models of inflammatory and postsurgical pain, but the mechanism underlying these effects is not known. We sought to determine the site of action of EGb 761 by investigating the antihyperalgesic and antiinflammatory properties of EGb 761 after local and central drug administration in the rat carrageenan model of inflammation.

Original language	English
Pages (from-to)	1226-1231
Number of pages	6
Journal	Anesthesia and Analgesia
Volume	122
Issue number	5
Publication status	Published - 1 May 2011

Keywords

hermal hyperalgesia
central drug administration
Gingko biloba
pain

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title = "Central and local administration of Gingko biloba extract EGb 761{\textregistered} inhibits thermal hyperalgesia and inflammation in the rat carrageenan model",

abstract = "Oral administration of the standardized Ginkgo biloba extract EGb 761{\textregistered} has been shown to inhibit thermal hyperalgesia in rodent models of inflammatory and postsurgical pain, but the mechanism underlying these effects is not known. We sought to determine the site of action of EGb 761 by investigating the antihyperalgesic and antiinflammatory properties of EGb 761 after local and central drug administration in the rat carrageenan model of inflammation.",

keywords = "hermal hyperalgesia, central drug administration, Gingko biloba, pain",

author = "Laura Biddlestone and Michelle Goldie and Sharron Dolan",

note = "<p>Originally published in: Anesthesia and Analgesia (2011), 112 (5), pp.1226-1231.</p>",

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T1 - Central and local administration of Gingko biloba extract EGb 761® inhibits thermal hyperalgesia and inflammation in the rat carrageenan model

AU - Biddlestone, Laura

AU - Goldie, Michelle

AU - Dolan, Sharron

N1 - <p>Originally published in: Anesthesia and Analgesia (2011), 112 (5), pp.1226-1231.</p>

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Oral administration of the standardized Ginkgo biloba extract EGb 761® has been shown to inhibit thermal hyperalgesia in rodent models of inflammatory and postsurgical pain, but the mechanism underlying these effects is not known. We sought to determine the site of action of EGb 761 by investigating the antihyperalgesic and antiinflammatory properties of EGb 761 after local and central drug administration in the rat carrageenan model of inflammation.

AB - Oral administration of the standardized Ginkgo biloba extract EGb 761® has been shown to inhibit thermal hyperalgesia in rodent models of inflammatory and postsurgical pain, but the mechanism underlying these effects is not known. We sought to determine the site of action of EGb 761 by investigating the antihyperalgesic and antiinflammatory properties of EGb 761 after local and central drug administration in the rat carrageenan model of inflammation.

KW - hermal hyperalgesia

KW - central drug administration

KW - Gingko biloba

KW - pain

M3 - Article

VL - 122

SP - 1226

EP - 1231

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

IS - 5

ER -

Central and local administration of Gingko biloba extract EGb 761® inhibits thermal hyperalgesia and inflammation in the rat carrageenan model

Abstract

Keywords

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