Cellular thiol production and oxidation of low-density lipoprotein

Annette Graham*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Compelling evidence suggests that low-density lipoprotein (LDL) is oxidized by cells within the arterial intima and that, once oxidized, it is profoundly atherogenic. The precise mechanism(s) by which cells promote the oxidation of LDL in vivo are not known; in vitro, however, oxidation of LDL can be enhanced by a number of differing mechanisms, including reaction with free and protein-bound metal ions, thiols, reactive oxygen species, lipoxygenase, myeloperoxidase and peroxynitrite. This review is concerned with the mechanisms by which cells enhance the oxidation of LDL in the presence of transition metals; in particular, the regulation, pro- and anti-oxidant consequences, and mechanism of action of cellular thiol production are examined, and contrasted with thiol-independent oxidation of LDL in the presence of transition metals.

Original languageEnglish
Pages (from-to)611-621
Number of pages11
JournalFree Radical Research
Volume28
Issue number6
DOIs
Publication statusPublished - Jan 1998
Externally publishedYes

Keywords

  • Atherosclerosis
  • Oxidized low-density lipoprotein
  • Thiol
  • Transition metal

ASJC Scopus subject areas

  • Biochemistry

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