Abstract
Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5.
| Original language | English |
|---|---|
| Pages (from-to) | 390-401 |
| Number of pages | 12 |
| Journal | Experimental Cell Research |
| Volume | 319 |
| Issue number | 4 |
| Early online date | 20 Dec 2012 |
| DOIs | |
| Publication status | Published - Feb 2013 |
Keywords
- wound healing
- diabetes
- Gap27
- Connexin43
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Wright, C., Berends, R., Flint, D. J., & Martin, P. (2013). Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5. Experimental Cell Research, 319(4), 390-401. https://doi.org/10.1016/j.yexcr.2012.12.013