Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5

Catherine Wright, Rebecca Berends, David J. Flint, Patricia Martin

Research output: Contribution to journalArticle

Abstract

Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5.
Original languageEnglish
Pages (from-to)390-401
Number of pages12
JournalExperimental Cell Research
Volume319
Issue number4
Early online date20 Dec 2012
DOIs
Publication statusPublished - Feb 2013

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Keywords

  • wound healing
  • diabetes
  • Gap27
  • Connexin43

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