Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5

Catherine Wright; Rebecca Berends; David J. Flint; Patricia Martin

doi:10.1016/j.yexcr.2012.12.013

Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5

Catherine Wright, Rebecca Berends, David J. Flint, Patricia Martin

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5.

Original language	English
Pages (from-to)	390-401
Number of pages	12
Journal	Experimental Cell Research
Volume	319
Issue number	4
Early online date	20 Dec 2012
DOIs	https://doi.org/10.1016/j.yexcr.2012.12.013
Publication status	Published - Feb 2013

Keywords

wound healing
diabetes
Gap27
Connexin43

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.yexcr.2012.12.013

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title = "Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5",

abstract = "Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5. ",

keywords = "wound healing, diabetes, Gap27, Connexin43",

author = "Catherine Wright and Rebecca Berends and Flint, {David J.} and Patricia Martin",

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journal = "Experimental Cell Research",

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AU - Wright, Catherine

AU - Berends, Rebecca

AU - Flint, David J.

AU - Martin, Patricia

PY - 2013/2

Y1 - 2013/2

N2 - Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5.

AB - Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5.

KW - wound healing

KW - diabetes

KW - Gap27

KW - Connexin43

U2 - 10.1016/j.yexcr.2012.12.013

DO - 10.1016/j.yexcr.2012.12.013

M3 - Article

VL - 319

SP - 390

EP - 401

JO - Experimental Cell Research

JF - Experimental Cell Research

SN - 0014-4827

IS - 4

ER -

Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5

Abstract

Keywords

UN SDGs

Documents and Links

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