Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5

Catherine Wright; Rebecca Berends; David J. Flint; Patricia Martin

doi:10.1016/j.yexcr.2012.12.013

Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5

Catherine Wright, Rebecca Berends, David J. Flint, Patricia Martin

Biological and Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5.

Original language	English
Pages (from-to)	390-401
Number of pages	12
Journal	Experimental Cell Research
Volume	319
Issue number	4
Early online date	20 Dec 2012
DOIs	https://doi.org/10.1016/j.yexcr.2012.12.013
Publication status	Published - Feb 2013

Fingerprint

Keywords

wound healing
diabetes
Gap27
Connexin43

Cite this

Wright, C., Berends, R., Flint, D. J., & Martin, P. (2013). Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5. Experimental Cell Research, 319(4), 390-401. https://doi.org/10.1016/j.yexcr.2012.12.013

@article{8421e3f847a44390a8cc02abab294601,

title = "Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5",

abstract = "Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5. ",

keywords = "wound healing, diabetes, Gap27, Connexin43",

author = "Catherine Wright and Rebecca Berends and Flint, {David J.} and Patricia Martin",

year = "2013",

month = feb,

doi = "10.1016/j.yexcr.2012.12.013",

language = "English",

volume = "319",

pages = "390--401",

journal = "Experimental Cell Research",

issn = "0014-4827",

publisher = "Elsevier B.V.",

number = "4",

}

TY - JOUR

T1 - Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5

AU - Wright, Catherine

AU - Berends, Rebecca

AU - Flint, David J.

AU - Martin, Patricia

PY - 2013/2

Y1 - 2013/2

N2 - Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5.

AB - Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5.

KW - wound healing

KW - diabetes

KW - Gap27

KW - Connexin43

U2 - 10.1016/j.yexcr.2012.12.013

DO - 10.1016/j.yexcr.2012.12.013

M3 - Article

VL - 319

SP - 390

EP - 401

JO - Experimental Cell Research

JF - Experimental Cell Research

SN - 0014-4827

IS - 4

ER -

Documents and Links

10.1016/j.yexcr.2012.12.013