Abstract
Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5.
Original language | English |
---|---|
Pages (from-to) | 390-401 |
Number of pages | 12 |
Journal | Experimental Cell Research |
Volume | 319 |
Issue number | 4 |
Early online date | 20 Dec 2012 |
DOIs | |
Publication status | Published - Feb 2013 |
Keywords
- wound healing
- diabetes
- Gap27
- Connexin43