Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5.
- wound healing
Wright, C., Berends, R., Flint, D. J., & Martin, P. (2013). Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5. Experimental Cell Research, 319(4), 390-401. https://doi.org/10.1016/j.yexcr.2012.12.013