Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPAR¿ as susceptibility loci

Gillian Hamilton; Petra Proitsi; Luke Jehu; Angharad Morgan; Julie Williams; Michael O'Donovan; Michael J. Owen; John F. Powell; Simon Lovestone

doi:10.1002/ajmg.b.30503

Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPAR¿ as susceptibility loci

Gillian Hamilton, Petra Proitsi, Luke Jehu, Angharad Morgan, Julie Williams, Michael O'Donovan, Michael J. Owen, John F. Powell, Simon Lovestone

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes—PPAR¿, SOS2, and PCK1—with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender.

Original language	English
Pages (from-to)	508-516
Number of pages	9
Journal	American journal of medical genetics. Part B
Volume	144
Issue number	4
DOIs	https://doi.org/10.1002/ajmg.b.30503
Publication status	Published - Apr 2007

Keywords

type 2 diabetes
Alzheimer's disease
genes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajmg.b.30503

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Hamilton, G., Proitsi, P., Jehu, L., Morgan, A., Williams, J., O'Donovan, M., Owen, M. J., Powell, J. F., & Lovestone, S. (2007). Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPAR¿ as susceptibility loci. American journal of medical genetics. Part B, 144(4), 508-516. https://doi.org/10.1002/ajmg.b.30503

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abstract = "Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes—PPAR¿, SOS2, and PCK1—with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender.",

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author = "Gillian Hamilton and Petra Proitsi and Luke Jehu and Angharad Morgan and Julie Williams and Michael O'Donovan and Owen, {Michael J.} and Powell, {John F.} and Simon Lovestone",

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Hamilton, G, Proitsi, P, Jehu, L, Morgan, A, Williams, J, O'Donovan, M, Owen, MJ, Powell, JF & Lovestone, S 2007, 'Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPAR¿ as susceptibility loci', American journal of medical genetics. Part B, vol. 144, no. 4, pp. 508-516. https://doi.org/10.1002/ajmg.b.30503

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T2 - evidence for SOS2, PCK1, and PPAR¿ as susceptibility loci

AU - Hamilton, Gillian

AU - Proitsi, Petra

AU - Jehu, Luke

AU - Morgan, Angharad

AU - Williams, Julie

AU - O'Donovan, Michael

AU - Owen, Michael J.

AU - Powell, John F.

AU - Lovestone, Simon

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N2 - Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes—PPAR¿, SOS2, and PCK1—with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender.

AB - Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes—PPAR¿, SOS2, and PCK1—with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender.

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KW - Alzheimer's disease

KW - genes

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DO - 10.1002/ajmg.b.30503

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SN - 1552-485X

VL - 144

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JO - American journal of medical genetics. Part B

JF - American journal of medical genetics. Part B

IS - 4

ER -

Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPAR¿ as susceptibility loci

Abstract

Keywords

UN SDGs

Documents and Links

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