Candida auris exhibits resilient biofilm characteristics in vitro: implications for environmental persistence

Bryn Short, Jason Brown, Christopher Delaney, Leighann Sherry, Craig Williams, Gordon Ramage, Ryan Kean

Research output: Contribution to journalArticle

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Abstract

Surfaces within healthcare play a key role in the transmission of drug-resistant pathogens. Candida auris is an emerging multidrug-resistant yeast which can survive for prolonged periods on environmental surfaces. Here we show that the ability to form cellular aggregates increases survival after 14 days, which coincides with the upregulation of biofilm-associated genes. Additionally, the aggregating strain demonstrated tolerance to clinical concentrations of sodium hypochlorite and remained viable 14 days post treatment. The ability of C. auris to adhere to and persist on environmental surfaces emphasizes our need to better understand the biology of this fungal pathogen.
Original languageEnglish
Pages (from-to)92-96
Number of pages5
JournalJournal of Hospital Infection
Volume103
Issue number1
Early online date18 Jun 2019
DOIs
Publication statusPublished - Sep 2019

Keywords

  • Candida auris
  • disinfection
  • surface
  • biofilm

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