Can arterial wave augmentation in young adults help account for variability of cardiovascular risk in different British ethnic groups?

Luca Faconti, Maria J. Silva, Oarabile R. Molaodi, Zinat E. Enayat, Aidan Cassidy, Alexis Karamanos, Elisa Nanino, Ursula M. Read, Philippa Dall, Ben Stansfield, Seeromanie Harding, Kennedy J. Cruickshank

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Abstract

Objective: Traditional cardiovascular risk factors do not fully account for ethnic differences in cardiovascular disease. We tested if arterial function indices, particularly augmentation index (AIx), and their determinants from childhood could underlie such ethnic variability among young British adults in the ‘DASH’ longitudinal study. Methods: DASH, at http://dash.sphsu.mrc.ac.uk/, includes representative samples of six main British ethnic groups. Pulse wave velocity (PWV) and AIx were recorded using the Arteriograph device at ages 21–23 years in a subsample (n¿=¿666); psychosocial, anthropometric, and blood pressure (BP) measures were collected then and in two previous surveys at ages 11–13 years and 14–16 years. For n¿=¿334, physical activity was measured over 5 days (ActivPal). Results: Unadjusted values and regression models for PWVs were similar or lower in ethnic minority than in White UK young adults, whereas AIx was higher – Caribbean (14.9, 95% confidence interval 12.3–17.0%), West African (15.3, 12.9–17.7%), Indian (15.1, 13.0–17.2%), and Pakistani/Bangladeshi (15.7, 13.7–17.7%), compared with White UK (11.9, 10.2–13.6%). In multivariate models, adjusted for sex, central SBP, height, and heart rate, Indian and Pakistani/Bangladeshi young adults had higher AIx (ß¿=¿3.35, 4.20, respectively, P¿<¿0.01) than White UK with a similar trend for West Africans and Caribbeans but not statistically significant. Unlike PWV, physical activity, psychosocial or deprivation measures were not associated with AIx, with borderline associations from brachial BP but no other childhood variables. Conclusion: Early adult AIx, but not arterial stiffness, may be a useful tool for testing components of excess cardiovascular risk in some ethnic minority groups.
Original languageEnglish
Pages (from-to)2220-2226
Number of pages7
JournalJournal of Hypertension
Volume34
Issue number11
Early online date19 Aug 2016
DOIs
Publication statusPublished - Nov 2016

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Ethnic Groups
Young Adult
Pulse Wave Analysis
Psychosocial Deprivation
Exercise
Blood Pressure
Minority Groups
Vascular Stiffness
Longitudinal Studies
Arm
Cardiovascular Diseases
Heart Rate
Confidence Intervals
Equipment and Supplies

Keywords

  • cardiology
  • ethnic differences
  • cardiovascular disease

Cite this

Faconti, L., Silva, M. J., Molaodi, O. R., Enayat, Z. E., Cassidy, A., Karamanos, A., ... Cruickshank, K. J. (2016). Can arterial wave augmentation in young adults help account for variability of cardiovascular risk in different British ethnic groups? Journal of Hypertension, 34(11), 2220-2226. https://doi.org/10.1097/HJH.0000000000001066
Faconti, Luca ; Silva, Maria J. ; Molaodi, Oarabile R. ; Enayat, Zinat E. ; Cassidy, Aidan ; Karamanos, Alexis ; Nanino, Elisa ; Read, Ursula M. ; Dall, Philippa ; Stansfield, Ben ; Harding, Seeromanie ; Cruickshank, Kennedy J. / Can arterial wave augmentation in young adults help account for variability of cardiovascular risk in different British ethnic groups?. In: Journal of Hypertension. 2016 ; Vol. 34, No. 11. pp. 2220-2226.
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title = "Can arterial wave augmentation in young adults help account for variability of cardiovascular risk in different British ethnic groups?",
abstract = "Objective: Traditional cardiovascular risk factors do not fully account for ethnic differences in cardiovascular disease. We tested if arterial function indices, particularly augmentation index (AIx), and their determinants from childhood could underlie such ethnic variability among young British adults in the ‘DASH’ longitudinal study. Methods: DASH, at http://dash.sphsu.mrc.ac.uk/, includes representative samples of six main British ethnic groups. Pulse wave velocity (PWV) and AIx were recorded using the Arteriograph device at ages 21–23 years in a subsample (n¿=¿666); psychosocial, anthropometric, and blood pressure (BP) measures were collected then and in two previous surveys at ages 11–13 years and 14–16 years. For n¿=¿334, physical activity was measured over 5 days (ActivPal). Results: Unadjusted values and regression models for PWVs were similar or lower in ethnic minority than in White UK young adults, whereas AIx was higher – Caribbean (14.9, 95{\%} confidence interval 12.3–17.0{\%}), West African (15.3, 12.9–17.7{\%}), Indian (15.1, 13.0–17.2{\%}), and Pakistani/Bangladeshi (15.7, 13.7–17.7{\%}), compared with White UK (11.9, 10.2–13.6{\%}). In multivariate models, adjusted for sex, central SBP, height, and heart rate, Indian and Pakistani/Bangladeshi young adults had higher AIx ({\ss}¿=¿3.35, 4.20, respectively, P¿<¿0.01) than White UK with a similar trend for West Africans and Caribbeans but not statistically significant. Unlike PWV, physical activity, psychosocial or deprivation measures were not associated with AIx, with borderline associations from brachial BP but no other childhood variables. Conclusion: Early adult AIx, but not arterial stiffness, may be a useful tool for testing components of excess cardiovascular risk in some ethnic minority groups.",
keywords = "cardiology, ethnic differences , cardiovascular disease",
author = "Luca Faconti and Silva, {Maria J.} and Molaodi, {Oarabile R.} and Enayat, {Zinat E.} and Aidan Cassidy and Alexis Karamanos and Elisa Nanino and Read, {Ursula M.} and Philippa Dall and Ben Stansfield and Seeromanie Harding and Cruickshank, {Kennedy J.}",
note = "Accepted: 8/7/16 Online pub: 19-8-16 (confirmed by BS) Funding: MRC - compliant as open access The study was funded by the Medical Research Council (MC_U130015185/MC_UU_12017/1/MC_UU_12017–13.), Chief Scientist Office (SPHSU13) and North Central London Research Consortium and the Primary Care Research Network.",
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month = "11",
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pages = "2220--2226",
journal = "Journal of Hypertension",
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publisher = "Lippincott Williams & Wilkins",
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Faconti, L, Silva, MJ, Molaodi, OR, Enayat, ZE, Cassidy, A, Karamanos, A, Nanino, E, Read, UM, Dall, P, Stansfield, B, Harding, S & Cruickshank, KJ 2016, 'Can arterial wave augmentation in young adults help account for variability of cardiovascular risk in different British ethnic groups?', Journal of Hypertension, vol. 34, no. 11, pp. 2220-2226. https://doi.org/10.1097/HJH.0000000000001066

Can arterial wave augmentation in young adults help account for variability of cardiovascular risk in different British ethnic groups? / Faconti, Luca; Silva, Maria J. ; Molaodi, Oarabile R.; Enayat, Zinat E.; Cassidy, Aidan; Karamanos, Alexis; Nanino, Elisa; Read, Ursula M.; Dall, Philippa; Stansfield, Ben; Harding, Seeromanie; Cruickshank, Kennedy J.

In: Journal of Hypertension, Vol. 34, No. 11, 11.2016, p. 2220-2226.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Can arterial wave augmentation in young adults help account for variability of cardiovascular risk in different British ethnic groups?

AU - Faconti, Luca

AU - Silva, Maria J.

AU - Molaodi, Oarabile R.

AU - Enayat, Zinat E.

AU - Cassidy, Aidan

AU - Karamanos, Alexis

AU - Nanino, Elisa

AU - Read, Ursula M.

AU - Dall, Philippa

AU - Stansfield, Ben

AU - Harding, Seeromanie

AU - Cruickshank, Kennedy J.

N1 - Accepted: 8/7/16 Online pub: 19-8-16 (confirmed by BS) Funding: MRC - compliant as open access The study was funded by the Medical Research Council (MC_U130015185/MC_UU_12017/1/MC_UU_12017–13.), Chief Scientist Office (SPHSU13) and North Central London Research Consortium and the Primary Care Research Network.

PY - 2016/11

Y1 - 2016/11

N2 - Objective: Traditional cardiovascular risk factors do not fully account for ethnic differences in cardiovascular disease. We tested if arterial function indices, particularly augmentation index (AIx), and their determinants from childhood could underlie such ethnic variability among young British adults in the ‘DASH’ longitudinal study. Methods: DASH, at http://dash.sphsu.mrc.ac.uk/, includes representative samples of six main British ethnic groups. Pulse wave velocity (PWV) and AIx were recorded using the Arteriograph device at ages 21–23 years in a subsample (n¿=¿666); psychosocial, anthropometric, and blood pressure (BP) measures were collected then and in two previous surveys at ages 11–13 years and 14–16 years. For n¿=¿334, physical activity was measured over 5 days (ActivPal). Results: Unadjusted values and regression models for PWVs were similar or lower in ethnic minority than in White UK young adults, whereas AIx was higher – Caribbean (14.9, 95% confidence interval 12.3–17.0%), West African (15.3, 12.9–17.7%), Indian (15.1, 13.0–17.2%), and Pakistani/Bangladeshi (15.7, 13.7–17.7%), compared with White UK (11.9, 10.2–13.6%). In multivariate models, adjusted for sex, central SBP, height, and heart rate, Indian and Pakistani/Bangladeshi young adults had higher AIx (ß¿=¿3.35, 4.20, respectively, P¿<¿0.01) than White UK with a similar trend for West Africans and Caribbeans but not statistically significant. Unlike PWV, physical activity, psychosocial or deprivation measures were not associated with AIx, with borderline associations from brachial BP but no other childhood variables. Conclusion: Early adult AIx, but not arterial stiffness, may be a useful tool for testing components of excess cardiovascular risk in some ethnic minority groups.

AB - Objective: Traditional cardiovascular risk factors do not fully account for ethnic differences in cardiovascular disease. We tested if arterial function indices, particularly augmentation index (AIx), and their determinants from childhood could underlie such ethnic variability among young British adults in the ‘DASH’ longitudinal study. Methods: DASH, at http://dash.sphsu.mrc.ac.uk/, includes representative samples of six main British ethnic groups. Pulse wave velocity (PWV) and AIx were recorded using the Arteriograph device at ages 21–23 years in a subsample (n¿=¿666); psychosocial, anthropometric, and blood pressure (BP) measures were collected then and in two previous surveys at ages 11–13 years and 14–16 years. For n¿=¿334, physical activity was measured over 5 days (ActivPal). Results: Unadjusted values and regression models for PWVs were similar or lower in ethnic minority than in White UK young adults, whereas AIx was higher – Caribbean (14.9, 95% confidence interval 12.3–17.0%), West African (15.3, 12.9–17.7%), Indian (15.1, 13.0–17.2%), and Pakistani/Bangladeshi (15.7, 13.7–17.7%), compared with White UK (11.9, 10.2–13.6%). In multivariate models, adjusted for sex, central SBP, height, and heart rate, Indian and Pakistani/Bangladeshi young adults had higher AIx (ß¿=¿3.35, 4.20, respectively, P¿<¿0.01) than White UK with a similar trend for West Africans and Caribbeans but not statistically significant. Unlike PWV, physical activity, psychosocial or deprivation measures were not associated with AIx, with borderline associations from brachial BP but no other childhood variables. Conclusion: Early adult AIx, but not arterial stiffness, may be a useful tool for testing components of excess cardiovascular risk in some ethnic minority groups.

KW - cardiology

KW - ethnic differences

KW - cardiovascular disease

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DO - 10.1097/HJH.0000000000001066

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