The cationic, alpha-helical frog skin antimicrobial peptide B2RP (brevinin-2-related peptide) shows sequence similarity to antimicrobial peptides belonging to the brevinin-2 family, but lacks the C-terminal cyclic heptapeptide domain (Cys-Lys-Xaa (4)-Cys). Synthetic B2RP produced a significant (p<0.05) stimulation of insulin release (148% of basal rate at a concentration of 1 muM with a maximum response of 222% of basal rate at a concentration of 3 muM) from BRIN-BD11 clonal beta-cells without increasing the release of the cytosolic enzyme, lactate dehydrogenase.
- type 2 diabetes
- insulin secretion
- antimicrobial peptides
- lactate dehydrogenase
Abdel-Wahab, Y., Patterson, S., Flatt, P., & Conlon, J. M. (2010). Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet. Hormone and Metabolic Research, 42(9), 652-656. https://doi.org/10.1055/s-0030-1254126