Abstract
The cationic, alpha-helical frog skin antimicrobial peptide B2RP (brevinin-2-related peptide) shows sequence similarity to antimicrobial peptides belonging to the brevinin-2 family, but lacks the C-terminal cyclic heptapeptide domain (Cys-Lys-Xaa (4)-Cys). Synthetic B2RP produced a significant (p<0.05) stimulation of insulin release (148% of basal rate at a concentration of 1 muM with a maximum response of 222% of basal rate at a concentration of 3 muM) from BRIN-BD11 clonal beta-cells without increasing the release of the cytosolic enzyme, lactate dehydrogenase.
Original language | English |
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Pages (from-to) | 652-656 |
Number of pages | 5 |
Journal | Hormone and Metabolic Research |
Volume | 42 |
Issue number | 9 |
DOIs | |
Publication status | Published - Aug 2010 |
Keywords
- type 2 diabetes
- insulin secretion
- B2RP
- antimicrobial peptides
- lactate dehydrogenase