Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet

Yasser Abdel-Wahab, Steven Patterson, Peter Flatt, J Michael Conlon

Research output: Contribution to journalArticle

Abstract

The cationic, alpha-helical frog skin antimicrobial peptide B2RP (brevinin-2-related peptide) shows sequence similarity to antimicrobial peptides belonging to the brevinin-2 family, but lacks the C-terminal cyclic heptapeptide domain (Cys-Lys-Xaa (4)-Cys). Synthetic B2RP produced a significant (p<0.05) stimulation of insulin release (148% of basal rate at a concentration of 1 muM with a maximum response of 222% of basal rate at a concentration of 3 muM) from BRIN-BD11 clonal beta-cells without increasing the release of the cytosolic enzyme, lactate dehydrogenase.
Original languageEnglish
Pages (from-to)652-656
Number of pages5
JournalHormone and Metabolic Research
Volume42
Issue number9
DOIs
Publication statusPublished - Aug 2010

Keywords

  • type 2 diabetes
  • insulin secretion
  • B2RP
  • antimicrobial peptides
  • lactate dehydrogenase

Fingerprint Dive into the research topics of 'Brevinin-2-related peptide and its [D4K] analogue stimulate insulin release in vitro and improve glucose tolerance in mice fed a high fat diet'. Together they form a unique fingerprint.

  • Cite this