BoTULS: a multicentre randomised controlled trial to evaluate the clinical effectiveness and cost-effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A

Lisa C. Shaw, Helen Rodgers, Christopher I.M. Price, Frederike van Wijck, Phil Shackley, Nick Steen, Michael P. Barnes, Gary A. Ford, Laura A. Graham

Research output: Contribution to journalArticle

Abstract

The study objective was to compare the clinical effectiveness and cost-effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A plus an upper limb therapy programme with the upper limb therapy programme alone. A multicentre open-label parallel-group randomised controlled trial and economic evaluation was carried out. Twelve stroke services in the north of England, UK. Participants: Three hundred and thirty-three adults with upper limb spasticity at the shoulder, elbow, wrist or hand and reduced upper limb function due to stroke more than 1 month previously.

Original languageEnglish
JournalHealth Technology Assessment
Volume14
Issue number26
Publication statusPublished - 1 May 2010

Keywords

  • botulinum toxin
  • stroke
  • randomized controlled trial
  • upper limb
  • spasticity
  • economic analysis

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