Botulinum toxin for the upper limb after stroke (BoTULS) trial: effect on impairment, activity limitation, and pain

Lisa C. Shaw; Christopher I.M. Price; Frederike van Wijck; Phil Shackley; Nick Steen; Michael P. Barnes; Gary A. Ford; Laura A. Graham; Helen Rodgers

doi:10.1161/STROKEAHA.110.582197

Botulinum toxin for the upper limb after stroke (BoTULS) trial: effect on impairment, activity limitation, and pain

Lisa C. Shaw, Christopher I.M. Price, Frederike van Wijck, Phil Shackley, Nick Steen, Michael P. Barnes, Gary A. Ford, Laura A. Graham, Helen Rodgers

Research output: Contribution to journal › Article

Abstract

Botulinum toxin is increasingly used to treat upper limb spasticity due to stroke, but its impact on arm function is unclear. We evaluated botulinum toxin for upper limb spasticity and function post stroke. Three hundred thirty-three patients with stroke with upper limb spasticity and reduced arm function participated in a multicenter randomized controlled trial. The intervention group received botulinum toxin type A injection(s) plus a 4-week therapy program. The control group received the therapy program alone. Repeat injection(s) and therapy were available at 3, 6, and 9 months. The primary outcome was upper limb function at 1 month (Action Research Arm Test). Secondary outcomes included measures of impairment, activity limitation, and pain at 1, 3, and 12 months. Outcome assessments were blinded and analysis was by intention to treat.

Original language	English
Pages (from-to)	1371-1379
Number of pages	9
Journal	Stroke
Volume	42
Issue number	5
DOIs	https://doi.org/10.1161/STROKEAHA.110.582197
Publication status	Published - Mar 2011

Keywords

botulinum toxin
stroke
randomized controlled trial
upper limb
spasticity

Documents and Links

10.1161/STROKEAHA.110.582197

Publication in Scopus

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Shaw, L. C., Price, C. I. M., van Wijck, F., Shackley, P., Steen, N., Barnes, M. P., Ford, G. A., Graham, L. A., & Rodgers, H. (2011). Botulinum toxin for the upper limb after stroke (BoTULS) trial: effect on impairment, activity limitation, and pain. Stroke, 42(5), 1371-1379. https://doi.org/10.1161/STROKEAHA.110.582197

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title = "Botulinum toxin for the upper limb after stroke (BoTULS) trial: effect on impairment, activity limitation, and pain",

abstract = "Botulinum toxin is increasingly used to treat upper limb spasticity due to stroke, but its impact on arm function is unclear. We evaluated botulinum toxin for upper limb spasticity and function post stroke. Three hundred thirty-three patients with stroke with upper limb spasticity and reduced arm function participated in a multicenter randomized controlled trial. The intervention group received botulinum toxin type A injection(s) plus a 4-week therapy program. The control group received the therapy program alone. Repeat injection(s) and therapy were available at 3, 6, and 9 months. The primary outcome was upper limb function at 1 month (Action Research Arm Test). Secondary outcomes included measures of impairment, activity limitation, and pain at 1, 3, and 12 months. Outcome assessments were blinded and analysis was by intention to treat.",

keywords = "botulinum toxin, stroke, randomized controlled trial, upper limb, spasticity",

author = "Shaw, {Lisa C.} and Price, {Christopher I.M.} and {van Wijck}, Frederike and Phil Shackley and Nick Steen and Barnes, {Michael P.} and Ford, {Gary A.} and Graham, {Laura A.} and Helen Rodgers",

note = "<p>Originally published in: Stroke (2011), published online ahead of print: <a href={"}http://dx.doi.org/10.1161/STROKEAHA.110.582197{"}>http://dx.doi.org/10.1161/STROKEAHA.110.582197</a></p>",

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Botulinum toxin for the upper limb after stroke (BoTULS) trial: effect on impairment, activity limitation, and pain. / Shaw, Lisa C.; Price, Christopher I.M.; van Wijck, Frederike; Shackley, Phil; Steen, Nick; Barnes, Michael P.; Ford, Gary A.; Graham, Laura A.; Rodgers, Helen.

In: Stroke, Vol. 42, No. 5, 03.2011, p. 1371-1379.

Research output: Contribution to journal › Article

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AU - Shaw, Lisa C.

AU - Price, Christopher I.M.

AU - van Wijck, Frederike

AU - Shackley, Phil

AU - Steen, Nick

AU - Barnes, Michael P.

AU - Ford, Gary A.

AU - Graham, Laura A.

AU - Rodgers, Helen

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AB - Botulinum toxin is increasingly used to treat upper limb spasticity due to stroke, but its impact on arm function is unclear. We evaluated botulinum toxin for upper limb spasticity and function post stroke. Three hundred thirty-three patients with stroke with upper limb spasticity and reduced arm function participated in a multicenter randomized controlled trial. The intervention group received botulinum toxin type A injection(s) plus a 4-week therapy program. The control group received the therapy program alone. Repeat injection(s) and therapy were available at 3, 6, and 9 months. The primary outcome was upper limb function at 1 month (Action Research Arm Test). Secondary outcomes included measures of impairment, activity limitation, and pain at 1, 3, and 12 months. Outcome assessments were blinded and analysis was by intention to treat.

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