Biomechanical factors associated with the development of tibiofemoral knee osteoarthritis: protocol for a systematic review and meta-analysis

Joyce A.C. van Tunen, Andrea Dell'Isola, Carsten Juhl, Joost Dekker, Martijn Steultjens, Hans Lund

Research output: Contribution to journalArticle

13 Downloads (Pure)

Abstract

Introduction Altered biomechanics, increased joint loading and tissue damage, might be related in a vicious cycle within the development of knee osteoarthritis (KOA). We have defined biomechanical factors as joint-related factors that interact with the forces, moments and kinematics in and around a synovial joint. Although a number of studies and systematic reviews have been performed to assess the association of various factors with the development of KOA, a comprehensive overview focusing on biomechanical factors that are associated with the development of KOA is not available. The aim of this review is (1) to identify biomechanical factors that are associated with (the development of) KOA and (2) to identify the impact of other relevant risk factors on this association.

Methods and analysis Cohort, cross-sectional and case–control studies investigating the association of a biomechanical factor with (the development of) KOA will be included. MEDLINE, EMBASE, CINAHL and SPORTDiscus will be searched from their inception until August 2015. 2 reviewers will independently screen articles obtained by the search for eligibility, extract data and score risk of bias. Quality of evidence will be evaluated. Meta-analysis using random effects model will be applied in each of the biomechanical factors, if possible.

Ethics and dissemination This systematic review and meta-analysis does not require ethical approval. The results of this systematic review and meta-analysis will be disseminated through publications in peer-reviewed journals and presentations at (inter)national conferences.

Trial registration number CRD42015025092.
Original languageEnglish
Article numbere011066
JournalBMJ Open
Volume6
DOIs
Publication statusPublished - 16 Jun 2016

Fingerprint

Knee Osteoarthritis
Meta-Analysis
Joints
Biomechanical Phenomena
Ethics
MEDLINE
Publications
Cohort Studies
Cross-Sectional Studies

Keywords

  • biomechanics
  • knee osteoarthritis
  • synovial joint

Cite this

@article{e33bc002b0634bf09df0459589ebf01d,
title = "Biomechanical factors associated with the development of tibiofemoral knee osteoarthritis: protocol for a systematic review and meta-analysis",
abstract = "Introduction Altered biomechanics, increased joint loading and tissue damage, might be related in a vicious cycle within the development of knee osteoarthritis (KOA). We have defined biomechanical factors as joint-related factors that interact with the forces, moments and kinematics in and around a synovial joint. Although a number of studies and systematic reviews have been performed to assess the association of various factors with the development of KOA, a comprehensive overview focusing on biomechanical factors that are associated with the development of KOA is not available. The aim of this review is (1) to identify biomechanical factors that are associated with (the development of) KOA and (2) to identify the impact of other relevant risk factors on this association.Methods and analysis Cohort, cross-sectional and case–control studies investigating the association of a biomechanical factor with (the development of) KOA will be included. MEDLINE, EMBASE, CINAHL and SPORTDiscus will be searched from their inception until August 2015. 2 reviewers will independently screen articles obtained by the search for eligibility, extract data and score risk of bias. Quality of evidence will be evaluated. Meta-analysis using random effects model will be applied in each of the biomechanical factors, if possible.Ethics and dissemination This systematic review and meta-analysis does not require ethical approval. The results of this systematic review and meta-analysis will be disseminated through publications in peer-reviewed journals and presentations at (inter)national conferences.Trial registration number CRD42015025092.",
keywords = "biomechanics, knee osteoarthritis, synovial joint",
author = "{van Tunen}, {Joyce A.C.} and Andrea Dell'Isola and Carsten Juhl and Joost Dekker and Martijn Steultjens and Hans Lund",
note = "OA article Funding The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7-PEOPLE-2013-ITN; KNEEMO) under grant agreement n 607510. This work was also supported by the Open Access Fund from the University of Southern Denmark.",
year = "2016",
month = "6",
day = "16",
doi = "10.1136/bmjopen-2016-011066",
language = "English",
volume = "6",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",

}

Biomechanical factors associated with the development of tibiofemoral knee osteoarthritis: protocol for a systematic review and meta-analysis. / van Tunen, Joyce A.C.; Dell'Isola, Andrea; Juhl, Carsten ; Dekker, Joost; Steultjens, Martijn; Lund, Hans.

In: BMJ Open, Vol. 6, e011066, 16.06.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Biomechanical factors associated with the development of tibiofemoral knee osteoarthritis: protocol for a systematic review and meta-analysis

AU - van Tunen, Joyce A.C.

AU - Dell'Isola, Andrea

AU - Juhl, Carsten

AU - Dekker, Joost

AU - Steultjens, Martijn

AU - Lund, Hans

N1 - OA article Funding The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7-PEOPLE-2013-ITN; KNEEMO) under grant agreement n 607510. This work was also supported by the Open Access Fund from the University of Southern Denmark.

PY - 2016/6/16

Y1 - 2016/6/16

N2 - Introduction Altered biomechanics, increased joint loading and tissue damage, might be related in a vicious cycle within the development of knee osteoarthritis (KOA). We have defined biomechanical factors as joint-related factors that interact with the forces, moments and kinematics in and around a synovial joint. Although a number of studies and systematic reviews have been performed to assess the association of various factors with the development of KOA, a comprehensive overview focusing on biomechanical factors that are associated with the development of KOA is not available. The aim of this review is (1) to identify biomechanical factors that are associated with (the development of) KOA and (2) to identify the impact of other relevant risk factors on this association.Methods and analysis Cohort, cross-sectional and case–control studies investigating the association of a biomechanical factor with (the development of) KOA will be included. MEDLINE, EMBASE, CINAHL and SPORTDiscus will be searched from their inception until August 2015. 2 reviewers will independently screen articles obtained by the search for eligibility, extract data and score risk of bias. Quality of evidence will be evaluated. Meta-analysis using random effects model will be applied in each of the biomechanical factors, if possible.Ethics and dissemination This systematic review and meta-analysis does not require ethical approval. The results of this systematic review and meta-analysis will be disseminated through publications in peer-reviewed journals and presentations at (inter)national conferences.Trial registration number CRD42015025092.

AB - Introduction Altered biomechanics, increased joint loading and tissue damage, might be related in a vicious cycle within the development of knee osteoarthritis (KOA). We have defined biomechanical factors as joint-related factors that interact with the forces, moments and kinematics in and around a synovial joint. Although a number of studies and systematic reviews have been performed to assess the association of various factors with the development of KOA, a comprehensive overview focusing on biomechanical factors that are associated with the development of KOA is not available. The aim of this review is (1) to identify biomechanical factors that are associated with (the development of) KOA and (2) to identify the impact of other relevant risk factors on this association.Methods and analysis Cohort, cross-sectional and case–control studies investigating the association of a biomechanical factor with (the development of) KOA will be included. MEDLINE, EMBASE, CINAHL and SPORTDiscus will be searched from their inception until August 2015. 2 reviewers will independently screen articles obtained by the search for eligibility, extract data and score risk of bias. Quality of evidence will be evaluated. Meta-analysis using random effects model will be applied in each of the biomechanical factors, if possible.Ethics and dissemination This systematic review and meta-analysis does not require ethical approval. The results of this systematic review and meta-analysis will be disseminated through publications in peer-reviewed journals and presentations at (inter)national conferences.Trial registration number CRD42015025092.

KW - biomechanics

KW - knee osteoarthritis

KW - synovial joint

U2 - 10.1136/bmjopen-2016-011066

DO - 10.1136/bmjopen-2016-011066

M3 - Article

VL - 6

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

M1 - e011066

ER -