TY - JOUR
T1 - Biomechanical factors associated with the development of tibiofemoral knee osteoarthritis: protocol for a systematic review and meta-analysis
AU - van Tunen, Joyce A.C.
AU - Dell'Isola, Andrea
AU - Juhl, Carsten
AU - Dekker, Joost
AU - Steultjens, Martijn
AU - Lund, Hans
N1 - OA article
Funding The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7-PEOPLE-2013-ITN; KNEEMO) under grant agreement n 607510. This work was also supported by the Open Access Fund from the University of Southern Denmark.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Introduction: Altered biomechanics, increased joint loading and tissue damage, might be related in a vicious cycle within the development of knee osteoarthritis (KOA). We have defined biomechanical factors as joint-related factors that interact with the forces, moments and kinematics in and around a synovial joint. Although a number of studies and systematic reviews have been performed to assess the association of various factors with the development of KOA, a comprehensive overview focusing on biomechanical factors that are associated with the development of KOA is not available. The aim of this review is (1) to identify biomechanical factors that are associated with (the development of ) KOA and (2) to identify the impact of other relevant risk factors on this association. Methods and analysis: Cohort, cross-sectional and case-control studies investigating the association of a biomechanical factor with (the development of ) KOA will be included. MEDLINE, EMBASE, CINAHL and SPORTDiscus will be searched from their inception until August 2015. 2 reviewers will independently screen articles obtained by the search for eligibility, extract data and score risk of bias. Quality of evidence will be evaluated. Meta-analysis using random effects model will be applied in each of the biomechanical factors, if possible. Ethics and dissemination: This systematic review and meta-analysis does not require ethical approval. The results of this systematic review and meta-analysis will be disseminated through publications in peerreviewed journals and presentations at (inter)national conferences.
AB - Introduction: Altered biomechanics, increased joint loading and tissue damage, might be related in a vicious cycle within the development of knee osteoarthritis (KOA). We have defined biomechanical factors as joint-related factors that interact with the forces, moments and kinematics in and around a synovial joint. Although a number of studies and systematic reviews have been performed to assess the association of various factors with the development of KOA, a comprehensive overview focusing on biomechanical factors that are associated with the development of KOA is not available. The aim of this review is (1) to identify biomechanical factors that are associated with (the development of ) KOA and (2) to identify the impact of other relevant risk factors on this association. Methods and analysis: Cohort, cross-sectional and case-control studies investigating the association of a biomechanical factor with (the development of ) KOA will be included. MEDLINE, EMBASE, CINAHL and SPORTDiscus will be searched from their inception until August 2015. 2 reviewers will independently screen articles obtained by the search for eligibility, extract data and score risk of bias. Quality of evidence will be evaluated. Meta-analysis using random effects model will be applied in each of the biomechanical factors, if possible. Ethics and dissemination: This systematic review and meta-analysis does not require ethical approval. The results of this systematic review and meta-analysis will be disseminated through publications in peerreviewed journals and presentations at (inter)national conferences.
KW - Biomechanical Phenomena
KW - Humans
KW - Osteoarthritis, Knee/etiology
KW - Research Design
KW - Risk Factors
KW - Systematic Reviews as Topic
U2 - 10.1136/bmjopen-2016-011066
DO - 10.1136/bmjopen-2016-011066
M3 - Article
C2 - 27311908
SN - 2044-6055
VL - 6
JO - BMJ Open
JF - BMJ Open
IS - 6
M1 - e011066
ER -