Biomechanical factors and physical examination findings in osteoarthritis of the knee: associations with tissue abnormalities assessed by conventional radiography and high resolution 3.0 Tesla magnetic resonance imaging

Jesper Knoop, Joost Dekker, JP Klein, Marike Van Der Leeden, Martin Van Der Esch, D Reiding, Ramon Voorneman, Martijn Gerritsen, Leo Roorda, Martijn Steultjens, Willem Lems

Research output: Contribution to journalArticle

Abstract

We aimed to explore the associations between knee osteoarthritis (OA)-related tissue abnormalities assessed by conventional radiography (CR) and high resolution 3.0 Tesla magnetic resonance imaging (MRI), as well as biomechanical factors and findings from physical examination in patients with knee OA. We observed clinically relevant findings, including a significant association between quadriceps weakness and both effusion and synovitis, detected by MRI. Inflammation was detected in over one third of the participants, emphasizing the inflammatory component of OA and a possible important role of anti-inflammatory therapies in knee OA. In general, OA-related tissue abnormalities of the knee, even those detected by MRI, were found to be discordant with biomechanical and physical examination features.
Original languageEnglish
Article numberR212
JournalArthritis Research & Therapy
Volume14
Issue number5
Early online date5 Oct 2012
DOIs
Publication statusPublished - 2012

Keywords

  • biomechanics
  • knee osteoarthritis
  • anti-inflammatory therapies
  • MRI

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