Bioindicators and reproductive effects of prolonged 17ß-oestradiol exposure in a marine fish, the sand goby (Pomatoschistus minutus)

Craig D. Robinson, Elaine Brown, John A. Craft, Ian M. Davies, Colin Megginson, Colin Miller, Colin F. Moffat

Research output: Contribution to journalArticle


The effects of 17ß-oestradiol (E2) on mortality, growth rates, sexual maturation, hepatic vitellogenin (VTG) mRNA expression and reproductive success were investigated during an 8-month, water-borne exposure of a marine fish, the sand goby (Pomatoschistus minutus). Indicators of oestrogenic exposure were investigated as predictors of population-level reproductive success. E2 exposure concentrations were (below limit of detection), 16 ± 3, 97 ± 20 and 669 ± 151 ng l-1 (bootstrap means and standard errors). The carrier solvent (ìl l-1 propan-2-ol) significantly reduced the rate of egg production compared to untreated fish, but did not significantly affect male VTG mRNA expression, brood size, or the other studied parameters.

Original languageEnglish
JournalAquatic Toxicology
Publication statusPublished - 1 Mar 2007



  • sand goby
  • vitellogenin
  • gene expression
  • reproduction
  • marine fish

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