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Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)
145 Downloads (Pure)

Abstract

Vulvovaginal candidiasis (VVC) is a global health problem affecting 75% of women at least once in their lifetime. Here we examined the epidemiology of VVC in a patient cohort to identify the causative organisms associated with VVC. Biofilm-forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm-forming capacity, which is associated with altered antifungal drug sensitivity.
Original languageEnglish
Article numbere01065-17
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number9
DOIs
Publication statusPublished - Sept 2017
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Antifungal Agents/therapeutic use
  • Biofilms/drug effects
  • Candida albicans/drug effects
  • Candida glabrata/drug effects
  • Candida parapsilosis/drug effects
  • Candida tropicalis/drug effects
  • Candidiasis, Vulvovaginal/drug therapy
  • Drug Resistance, Fungal
  • Female
  • Fluconazole/therapeutic use
  • Humans
  • Microbial Sensitivity Tests
  • Vaginal Smears
  • Vulvovaginal candidiasis
  • Fluconazole
  • Candida
  • Biofilm

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology

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