Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole

Leighann Sherry; Ryan Kean; Emily McKloud; Lindsay E. O'Donnell; Rebecca Metcalfe; Brian L. Jones; Gordon Ramage

doi:10.1128/AAC.01065-17

Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole

Leighann Sherry, Ryan Kean, Emily McKloud, Lindsay E. O'Donnell, Rebecca Metcalfe, Brian L. Jones, Gordon Ramage

Research output: Contribution to journal › Article

57 Downloads (Pure)

Abstract

Vulvovaginal candidiasis (VVC) is a global health problem affecting $75% of women at least once in their lifetime. Here we examined the epidemiology of VVC from a patient cohort to identify the causative organisms associated with VVC. Biofilm forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm forming capacity, both of which are associated with altered antifungal drug sensitivity.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	9
DOIs	https://doi.org/10.1128/AAC.01065-17
Publication status	Published - 24 Aug 2017

Keywords

biofilms
candidiasis patients

Documents and Links

10.1128/AAC.01065-17

Sherry, L. et al (2017) Biofilms formed by isolates from recurrent vulvovaginal candidiasis 2 patients are heterogeneous and insensitive to fluconazole
Published by American Society for Microbiology.Copyright © 2017 American Society for Microbiology.
Accepted author manuscript, 477 KB

Fingerprint Dive into the research topics of 'Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole'. Together they form a unique fingerprint.

Cite this

Sherry, L., Kean, R., McKloud, E., O'Donnell, L. E., Metcalfe, R., Jones, B. L., & Ramage, G. (2017). Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole. Antimicrobial Agents and Chemotherapy, 61(9). https://doi.org/10.1128/AAC.01065-17

@article{8643ab3183774aabaf329673c31b1560,

title = "Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole",

abstract = "Vulvovaginal candidiasis (VVC) is a global health problem affecting $75% of women at least once in their lifetime. Here we examined the epidemiology of VVC from a patient cohort to identify the causative organisms associated with VVC. Biofilm forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm forming capacity, both of which are associated with altered antifungal drug sensitivity.",

keywords = "biofilms, candidiasis patients",

author = "Leighann Sherry and Ryan Kean and Emily McKloud and O'Donnell, {Lindsay E.} and Rebecca Metcalfe and Jones, {Brian L.} and Gordon Ramage",

note = "Acceptance from webpage AAM from Enlighten Author (x2) start date at GCU is after acceptance > apply exception 254a. ET 13/11/19 ",

year = "2017",

month = aug,

day = "24",

doi = "10.1128/AAC.01065-17",

language = "English",

volume = "61",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "9",

}

Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole. / Sherry, Leighann; Kean, Ryan; McKloud, Emily; O'Donnell, Lindsay E.; Metcalfe, Rebecca; Jones, Brian L.; Ramage, Gordon.

In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 9, 24.08.2017.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole

AU - Sherry, Leighann

AU - Kean, Ryan

AU - McKloud, Emily

AU - O'Donnell, Lindsay E.

AU - Metcalfe, Rebecca

AU - Jones, Brian L.

AU - Ramage, Gordon

N1 - Acceptance from webpage AAM from Enlighten Author (x2) start date at GCU is after acceptance > apply exception 254a. ET 13/11/19

PY - 2017/8/24

Y1 - 2017/8/24

N2 - Vulvovaginal candidiasis (VVC) is a global health problem affecting $75% of women at least once in their lifetime. Here we examined the epidemiology of VVC from a patient cohort to identify the causative organisms associated with VVC. Biofilm forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm forming capacity, both of which are associated with altered antifungal drug sensitivity.

AB - Vulvovaginal candidiasis (VVC) is a global health problem affecting $75% of women at least once in their lifetime. Here we examined the epidemiology of VVC from a patient cohort to identify the causative organisms associated with VVC. Biofilm forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm forming capacity, both of which are associated with altered antifungal drug sensitivity.

KW - biofilms

KW - candidiasis patients

U2 - 10.1128/AAC.01065-17

DO - 10.1128/AAC.01065-17

M3 - Article

VL - 61

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 9

ER -