Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole

Leighann Sherry; Ryan Kean; Emily McKloud; Lindsay E. O'Donnell; Rebecca Metcalfe; Brian L. Jones; Gordon Ramage

doi:10.1128/AAC.01065-17

Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole

Leighann Sherry, Ryan Kean, Emily McKloud, Lindsay E. O'Donnell, Rebecca Metcalfe, Brian L. Jones, Gordon Ramage

Research output: Contribution to journal › Article › peer-review

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Abstract

Vulvovaginal candidiasis (VVC) is a global health problem affecting $75% of women at least once in their lifetime. Here we examined the epidemiology of VVC from a patient cohort to identify the causative organisms associated with VVC. Biofilm forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm forming capacity, both of which are associated with altered antifungal drug sensitivity.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	9
DOIs	https://doi.org/10.1128/AAC.01065-17
Publication status	Published - 24 Aug 2017

Keywords

biofilms
candidiasis patients

Documents and Links

10.1128/AAC.01065-17

Sherry, L. et al (2017) Biofilms formed by isolates from recurrent vulvovaginal candidiasis 2 patients are heterogeneous and insensitive to fluconazole
Published by American Society for Microbiology.Copyright © 2017 American Society for Microbiology.
Accepted author manuscript, 477 KB

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title = "Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole",

abstract = "Vulvovaginal candidiasis (VVC) is a global health problem affecting $75% of women at least once in their lifetime. Here we examined the epidemiology of VVC from a patient cohort to identify the causative organisms associated with VVC. Biofilm forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm forming capacity, both of which are associated with altered antifungal drug sensitivity.",

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Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole. / Sherry, Leighann; Kean, Ryan; McKloud, Emily; O'Donnell, Lindsay E.; Metcalfe, Rebecca; Jones, Brian L.; Ramage, Gordon.

In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 9, 24.08.2017.

Research output: Contribution to journal › Article › peer-review

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AU - Sherry, Leighann

AU - Kean, Ryan

AU - McKloud, Emily

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AU - Metcalfe, Rebecca

AU - Jones, Brian L.

AU - Ramage, Gordon

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AB - Vulvovaginal candidiasis (VVC) is a global health problem affecting $75% of women at least once in their lifetime. Here we examined the epidemiology of VVC from a patient cohort to identify the causative organisms associated with VVC. Biofilm forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm forming capacity, both of which are associated with altered antifungal drug sensitivity.

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KW - candidiasis patients

U2 - 10.1128/AAC.01065-17

DO - 10.1128/AAC.01065-17

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JO - Antimicrobial Agents and Chemotherapy

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