Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole

Leighann Sherry, Ryan Kean, Emily McKloud, Lindsay E. O'Donnell, Rebecca Metcalfe, Brian L. Jones, Gordon Ramage

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Abstract

Vulvovaginal candidiasis (VVC) is a global health problem affecting 75% of women at least once in their lifetime. Here we examined the epidemiology of VVC in a patient cohort to identify the causative organisms associated with VVC. Biofilm-forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm-forming capacity, which is associated with altered antifungal drug sensitivity.
Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number9
DOIs
Publication statusPublished - Sep 2017

Keywords

  • Antifungal Agents/therapeutic use
  • Biofilms/drug effects
  • Candida albicans/drug effects
  • Candida glabrata/drug effects
  • Candida parapsilosis/drug effects
  • Candida tropicalis/drug effects
  • Candidiasis, Vulvovaginal/drug therapy
  • Drug Resistance, Fungal
  • Female
  • Fluconazole/therapeutic use
  • Humans
  • Microbial Sensitivity Tests
  • Vaginal Smears

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