TY - JOUR
T1 - Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole
AU - Sherry, Leighann
AU - Kean, Ryan
AU - McKloud, Emily
AU - O'Donnell, Lindsay E.
AU - Metcalfe, Rebecca
AU - Jones, Brian L.
AU - Ramage, Gordon
N1 - Acceptance from webpage
AAM from Enlighten
Author (x2) start date at GCU is after acceptance > apply exception 254a. ET 13/11/19
PY - 2017/9
Y1 - 2017/9
N2 - Vulvovaginal candidiasis (VVC) is a global health problem affecting 75% of women at least once in their lifetime. Here we examined the epidemiology of VVC in a patient cohort to identify the causative organisms associated with VVC. Biofilm-forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm-forming capacity, which is associated with altered antifungal drug sensitivity.
AB - Vulvovaginal candidiasis (VVC) is a global health problem affecting 75% of women at least once in their lifetime. Here we examined the epidemiology of VVC in a patient cohort to identify the causative organisms associated with VVC. Biofilm-forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm-forming capacity, which is associated with altered antifungal drug sensitivity.
KW - Antifungal Agents/therapeutic use
KW - Biofilms/drug effects
KW - Candida albicans/drug effects
KW - Candida glabrata/drug effects
KW - Candida parapsilosis/drug effects
KW - Candida tropicalis/drug effects
KW - Candidiasis, Vulvovaginal/drug therapy
KW - Drug Resistance, Fungal
KW - Female
KW - Fluconazole/therapeutic use
KW - Humans
KW - Microbial Sensitivity Tests
KW - Vaginal Smears
U2 - 10.1128/AAC.01065-17
DO - 10.1128/AAC.01065-17
M3 - Article
C2 - 28696240
VL - 61
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 9
ER -