Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole

Leighann Sherry, Ryan Kean, Emily McKloud, Lindsay E. O'Donnell, Rebecca Metcalfe, Brian L. Jones, Gordon Ramage

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Abstract

Vulvovaginal candidiasis (VVC) is a global health problem affecting $75% of women at least once in their lifetime. Here we examined the epidemiology of VVC from a patient cohort to identify the causative organisms associated with VVC. Biofilm forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm forming capacity, both of which are associated with altered antifungal drug sensitivity.
Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number9
DOIs
Publication statusPublished - 24 Aug 2017

Keywords

  • biofilms
  • candidiasis patients

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