Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rat

Michelle Goldie, Sharron Dolan

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Standardized Ginkgo biloba extract EGb 761 has been shown to inhibit inflammatory hyperalgesia in rats; however, the mechanism of action is not known. This study set out to investigate the anti-inflammatory and analgesic potential of bilobalide, a unique G. biloba constituent, in three well-characterized models of acute inflammatory pain. The effect of oral, intraplantar or intrathecal administration of bilobalide or drug-vehicle (0.25% agar; 10% ethanol in H2O) on responses to noxious thermal and mechanical stimulation of the hindpaw, and paw oedema were assessed in adult male Wistar rats before and after intradermal hindpaw injection of carrageenan (3%; 50 µl) or capsaicin (10 µg; 50 µl) or after hindpaw incision (n=6-8/group). Oral administration of bilobalide (10-30 mg/kg) significantly inhibited thermal hyperalgesia in response to carrageenan, capsaicin and paw incision, independent of dose, with an efficacy similar to that of diclofenac.
Original languageEnglish
Pages (from-to)298-306
Number of pages9
JournalBehavioural Pharmacology
Issue number4
Publication statusPublished - Aug 2013


  • analgesia
  • bilobalide
  • Ginkgo biloba
  • carrageenan
  • paw incision


Dive into the research topics of 'Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rat'. Together they form a unique fingerprint.

Cite this