Baseline serum urate and 90-day functional outcomes following acute ischemic stroke

Jesse Dawson; Kennedy R. Lees; Christopher J. Weir; Terry Quinn; Myzoon Ali; Michael G. Hennerici; Matthew R. Walters

doi:10.1159/000226580

Baseline serum urate and 90-day functional outcomes following acute ischemic stroke

Jesse Dawson, Kennedy R. Lees, Christopher J. Weir, Terry Quinn, Myzoon Ali, Michael G. Hennerici, Matthew R. Walters

Research output: Contribution to journal › Article › peer-review

Abstract

It is increasingly recognized that there is an association between elevated serum urate and cardiovascular morbidity and mortality [1, 2] . This relationship is consistently apparent in cohorts with vascular risk factors and those with established cardio-vascular disease. However, the situation is less clear in the acute period after stroke. Some studies show that increasing serum
urate levels link with worse outcome [3] and risk of early clinical
deterioration [4] while others report a link with good outcome [5] .
There are biological reasons for and against a beneficial effect of
urate in the peri-infarct period but unfortunately available evidence
does not allow us to draw conclusions either way. Also, no
study has evaluated the association with 90-day functional outcome,
the standard used in clinical trials. We explored this association
using data from the Virtual International Stroke Trials
Archive (VISTA) [6] resource.

Original language	English
Pages (from-to)	202-203
Number of pages	2
Journal	Cerebrovascular Diseases
Volume	28
Early online date	30 Jun 2009
DOIs	https://doi.org/10.1159/000226580
Publication status	Published - Jun 2009

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title = "Baseline serum urate and 90-day functional outcomes following acute ischemic stroke",

abstract = "It is increasingly recognized that there is an association between elevated serum urate and cardiovascular morbidity and mortality [1, 2] . This relationship is consistently apparent in cohorts with vascular risk factors and those with established cardio-vascular disease. However, the situation is less clear in the acute period after stroke. Some studies show that increasing serum urate levels link with worse outcome [3] and risk of early clinical deterioration [4] while others report a link with good outcome [5] . There are biological reasons for and against a beneficial effect of urate in the peri-infarct period but unfortunately available evidence does not allow us to draw conclusions either way. Also, no study has evaluated the association with 90-day functional outcome, the standard used in clinical trials. We explored this association using data from the Virtual International Stroke Trials Archive (VISTA) [6] resource.",

author = "Jesse Dawson and Lees, {Kennedy R.} and Weir, {Christopher J.} and Terry Quinn and Myzoon Ali and Hennerici, {Michael G.} and Walters, {Matthew R.}",

year = "2009",

month = jun,

doi = "10.1159/000226580",

language = "English",

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journal = "Cerebrovascular Diseases",

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T1 - Baseline serum urate and 90-day functional outcomes following acute ischemic stroke

AU - Dawson, Jesse

AU - Lees, Kennedy R.

AU - Weir, Christopher J.

AU - Quinn, Terry

AU - Ali, Myzoon

AU - Hennerici, Michael G.

AU - Walters, Matthew R.

PY - 2009/6

Y1 - 2009/6

N2 - It is increasingly recognized that there is an association between elevated serum urate and cardiovascular morbidity and mortality [1, 2] . This relationship is consistently apparent in cohorts with vascular risk factors and those with established cardio-vascular disease. However, the situation is less clear in the acute period after stroke. Some studies show that increasing serum urate levels link with worse outcome [3] and risk of early clinical deterioration [4] while others report a link with good outcome [5] . There are biological reasons for and against a beneficial effect of urate in the peri-infarct period but unfortunately available evidence does not allow us to draw conclusions either way. Also, no study has evaluated the association with 90-day functional outcome, the standard used in clinical trials. We explored this association using data from the Virtual International Stroke Trials Archive (VISTA) [6] resource.

AB - It is increasingly recognized that there is an association between elevated serum urate and cardiovascular morbidity and mortality [1, 2] . This relationship is consistently apparent in cohorts with vascular risk factors and those with established cardio-vascular disease. However, the situation is less clear in the acute period after stroke. Some studies show that increasing serum urate levels link with worse outcome [3] and risk of early clinical deterioration [4] while others report a link with good outcome [5] . There are biological reasons for and against a beneficial effect of urate in the peri-infarct period but unfortunately available evidence does not allow us to draw conclusions either way. Also, no study has evaluated the association with 90-day functional outcome, the standard used in clinical trials. We explored this association using data from the Virtual International Stroke Trials Archive (VISTA) [6] resource.

U2 - 10.1159/000226580

DO - 10.1159/000226580

M3 - Article

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SP - 202

EP - 203

JO - Cerebrovascular Diseases

JF - Cerebrovascular Diseases

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