Baseline serum urate and 90-day functional outcomes following acute ischemic stroke

Jesse Dawson, Kennedy R. Lees, Christopher J. Weir, Terry Quinn, Myzoon Ali, Michael G. Hennerici, Matthew R. Walters

    Research output: Contribution to journalArticlepeer-review

    Abstract

    It is increasingly recognized that there is an association between elevated serum urate and cardiovascular morbidity and mortality [1, 2] . This relationship is consistently apparent in cohorts with vascular risk factors and those with established cardio-vascular disease. However, the situation is less clear in the acute period after stroke. Some studies show that increasing serum
    urate levels link with worse outcome [3] and risk of early clinical
    deterioration [4] while others report a link with good outcome [5] .
    There are biological reasons for and against a beneficial effect of
    urate in the peri-infarct period but unfortunately available evidence
    does not allow us to draw conclusions either way. Also, no
    study has evaluated the association with 90-day functional outcome,
    the standard used in clinical trials. We explored this association
    using data from the Virtual International Stroke Trials
    Archive (VISTA) [6] resource.
    Original languageEnglish
    Pages (from-to)202-203
    Number of pages2
    JournalCerebrovascular Diseases
    Volume28
    Early online date30 Jun 2009
    DOIs
    Publication statusPublished - Jun 2009

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