Azole resistance of Aspergillus fumigatus biofilms is partly associated with efflux pump activity

Ranjith Rajendran, Eilidh Mowat, Elaine McCulloch, David Lappin, Brian Jones, Sue Lang, Jayesh B. Majithiya, Peter Warn

Research output: Contribution to journalArticle

Abstract

This study investigated the phase dependant expression and activity of efflux pumps in Aspergillus fumigatus treated with voriconazole. Fourteen strains were shown to become increasingly resistant at the 12 h (16-128 fold) and 24 h (>512) phases compared to 8 h germlings. An Ala-Nap uptake assay demonstrated a significant increase in efflux pump activity in the 12 h and 24 h phases (p cells was also significantly induced by voriconazole treatment (p

Original languageEnglish
Pages (from-to)2092-2097
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number5
DOIs
Publication statusPublished - 1 Feb 2011

Keywords

  • Aspergillus fumigatus
  • aspergillosis
  • voriconazole
  • antimicrobial agents

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    Rajendran, R., Mowat, E., McCulloch, E., Lappin, D., Jones, B., Lang, S., Majithiya, J. B., & Warn, P. (2011). Azole resistance of Aspergillus fumigatus biofilms is partly associated with efflux pump activity. Antimicrobial Agents and Chemotherapy, 55(5), 2092-2097. https://doi.org/10.1128/AAC.01189-10