Abstract
This study investigated the phase dependant expression and activity of efflux pumps in Aspergillus fumigatus treated with voriconazole. Fourteen strains were shown to become increasingly resistant at the 12 h (16-128 fold) and 24 h (>512) phases compared to 8 h germlings. An Ala-Nap uptake assay demonstrated a significant increase in efflux pump activity in the 12 h and 24 h phases (p cells was also significantly induced by voriconazole treatment (p
Original language | English |
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Pages (from-to) | 2092-2097 |
Number of pages | 6 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 55 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 Feb 2011 |
Keywords
- Aspergillus fumigatus
- aspergillosis
- voriconazole
- antimicrobial agents