Associations of sedentary and physically-active behaviors with cognitive-function decline in community-dwelling older adults: compositional data analysis from the NEIGE study

Shiho Amagasa, Shigeru Inoue*, Hiroshi Murayama, Takeo Fujiwara, Hiroyuki Kikuchi, Noritoshi Fukushima, Masaki Machida, Sebastien Chastin, Neville Owen, Yugo Shobugawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Physical activity can help to protect against cognitive decline in older adults. However, little is known about the potential combined relationships of time spent in sedentary behavior (SB), light-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) with indices of cognitive health. We examined the cross-sectional associations of objectively-determined sedentary and physically-active behaviors with an indicator of cognitive function decline (CFD) in older adults.

METHODS: A randomly-recruited sample of 511 Japanese older adults (47% male; aged 65-84 years) wore a tri-axial accelerometer for 7 consecutive days in 2017. Cognitive function was assessed by interviewers using the Japanese version of Mini-Mental State Examination, with a score of ≤23 indicating CFD. Associations of sedentary and physically-active behaviors with CFD were examined using a compositional logistic regression analysis based on isometric log-ratio transformations of time use, adjusting for potential confounders.

RESULTS: Forty one (9.4%) of the participants had an indication of CFD. Activity compositions differed significantly between CFD and normal cognitive function (NCF); the proportion of time spent in MVPA was 39.1% lower, relative to the overall mean composition in those with CFD, and was 5.3% higher in those with NCF. There was a significant beneficial association of having a higher proportion of MVPA relative to other activities with CFD. LPA and SB were not associated with CFD when models were corrected for time spent in all activity behaviors.

CONCLUSIONS: Larger relative contribution of MVPA was favorably associated with an indicator of CFD in older adults.

Original languageEnglish
Pages (from-to)503-508
Number of pages6
JournalJournal of epidemiology
Volume30
Issue number11
Early online date26 Oct 2019
DOIs
Publication statusPublished - 5 Nov 2020

Keywords

  • accelerometry; aging; exercise; sedentary lifestyle; neurocognitive disorders

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