Associations of objectively-assessed physical activity and sedentary time with hippocampal gray matter volume in children with overweight/obesity

Jairo H. Migueles*, Cristina Cadenas-Sanchez, Irene Esteban-Cornejo, Lucia V. Torres-Lopez, Eivind Aadland, Sébastien F. Chastin, Kirk I. Erickson, Andres Catena, Francisco B. Ortega

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigated physical activity (PA) and sedentary time (SED) in relation to hippocampal gray matter volume (GMV) in pediatric overweight/obesity. Ninety-three children (10 ± 1 year) were classified as overweight, obesity type I, or type II-III. PA was assessed with non-dominant wrist accelerometers. GMV was acquired by magnetic resonance imaging (MRI). Neither PA nor SED associated with GMV in the hippocampus in the whole sample (p > 0.05). However, we found some evidence of moderation by weight status (p < 0.150). Moderate-to-vigorous PA (MVPA) positively associated with GMV in the right hippocampus in obesity type I (B = 5.62, p = 0.017), which remained when considering SED, light PA, and sleep using compositional data (γ = 375.3, p = 0.04). Compositional models also depicted a negative association of SED relative to the remaining behaviors with GMV in the right hippocampus in overweight (γ = -1838.4, p = 0.038). Reallocating 20 min/day of SED to MVPA was associated with 100 mm3 GMV in the right hippocampus in obesity type I. Multivariate pattern analysis showed a negative-to-positive association pattern between PA of increasing intensity and GMV in the right hippocampus in obesity type II-III. Our findings support that reducing SED and increasing MVPA are associated with greater GMV in the right hippocampus in pediatric overweight/obesity. Further studies should corroborate our findings.

Original languageEnglish
Article number1080
Number of pages16
JournalJournal of Clinical Medicine
Volume9
Issue number4
DOIs
Publication statusPublished - 10 Apr 2020

Keywords

  • physical behavior; sedentary behavior; brain health; youth; pre-adolescent

Fingerprint

Dive into the research topics of 'Associations of objectively-assessed physical activity and sedentary time with hippocampal gray matter volume in children with overweight/obesity'. Together they form a unique fingerprint.

Cite this