Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts

Marwah M. Bakri, Alistair D. Sutherland, Derek J. Brown, Pavel Vesely, Claire Crossan, Linda Scobie

Research output: Contribution to journalArticle

Abstract

There are numerous concerns over the potential for transfer of pathogens between species during clinical xenotransplantation, and although current clinical application is limited, porcine xenografts have been previously used to treat patients with severe burns. Donor animals providing the xenografts are sourced from a healthy commercial herd, however, as pigs are a known source of zoonotic agents, a number of diseases are required to be excluded from pigs used for xenotransplantation purposes. Many studies have indicated the relevance of viral zoonoses, however, little has been done with regard to the potential for transfer of pathogens related to health care associated infections.

Original languageEnglish
Pages (from-to)472-476
Number of pages5
JournalXenotransplantation
Volume16
Issue number6
DOIs
Publication statusPublished - 1 Dec 2009

Keywords

  • xenotransplantation
  • retrovirus infection
  • pigs

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