TY - JOUR
T1 - Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
AU - Godwin, Jon
N1 - <p>Originally published in: The Lancet (2009), 373 (9678), 1849-1860.</p>
PY - 2009/5/1
Y1 - 2009/5/1
N2 - Low-dose aspirin is of definite and substantial net benefit for many people who already have occlusive vascular disease. We have assessed the benefits and risks in primary prevention. We undertook meta-analyses of serious vascular events (myocardial infarction, stroke, or vascular death) and major bleeds in six primary prevention trials (95 000 individuals at low average risk, 660 000 person-years, 3554 serious vascular events) and 16 secondary prevention trials (17 000 individuals at high average risk, 43 000 person-years, 3306 serious vascular events) that compared long-term aspirin versus control. We report intention-to-treat analyses of first events during the scheduled treatment period. Jon Godwin is a member of the ATT Collaboration, the group author of this article.
AB - Low-dose aspirin is of definite and substantial net benefit for many people who already have occlusive vascular disease. We have assessed the benefits and risks in primary prevention. We undertook meta-analyses of serious vascular events (myocardial infarction, stroke, or vascular death) and major bleeds in six primary prevention trials (95 000 individuals at low average risk, 660 000 person-years, 3554 serious vascular events) and 16 secondary prevention trials (17 000 individuals at high average risk, 43 000 person-years, 3306 serious vascular events) that compared long-term aspirin versus control. We report intention-to-treat analyses of first events during the scheduled treatment period. Jon Godwin is a member of the ATT Collaboration, the group author of this article.
KW - aspirin
KW - vascular disease
KW - clinical trials
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-65849268320&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(09)60503-1
DO - 10.1016/S0140-6736(09)60503-1
M3 - Article
VL - 373
SP - 1849
EP - 1860
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 9678
ER -