TY - JOUR
T1 - Are glucose profiles well-controlled within the targets recommended by the International Diabetes Federation in type 2 diabetes? A meta-analysis of results from continuous glucose monitoring based studies
AU - Paing, Aye C.
AU - Kirk, Alison F.
AU - Collier, Andrew
AU - Kubiak, Thomas
AU - Chastin, Sebastien F.M.
N1 - Acceptance from webpage
AAM: 12m embargo
Available in Strathprints - find out deposit and access dates. ET
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Aims: To assess continuous glucose monitoring (CGM) derived intra-day glucose profiles using global guideline for type 2 diabetes recommended by the International Diabetes Federation (IDF). Methods: The Cochrane Library, MEDLINE, PubMed, CINAHL and Science Direct were searched to identify observational studies reporting intra-day glucose profiles using CGM in people with type 2 diabetes on any anti-diabetes agents. Overall and subgroup analyses were conducted to summarise mean differences between reported glucose profiles (fasting glucose, pre-meal glucose, postprandial glucose and post-meal glucose spike/excursion) and the IDF targets. Results: Twelve observational studies totalling 731 people were included. Pooled fasting glucose (0.81 mmol/L, 95% CI, 0.53–1.09 mmol/L), postprandial glucose after breakfast (1.63 mmol/L, 95% CI, 0.79–2.48 mmol/L) and post-breakfast glucose spike (1.05 mmol/L, 95% CI, 0.13–1.96 mmol/L) were significantly higher than the IDF targets. Pre-lunch glucose, pre-dinner glucose and postprandial glucose after lunch and dinner were above the IDF targets but not significantly. Subgroup analysis showed significantly higher fasting glucose and postprandial glucose after breakfast in all groups: HbA1c
AB - Aims: To assess continuous glucose monitoring (CGM) derived intra-day glucose profiles using global guideline for type 2 diabetes recommended by the International Diabetes Federation (IDF). Methods: The Cochrane Library, MEDLINE, PubMed, CINAHL and Science Direct were searched to identify observational studies reporting intra-day glucose profiles using CGM in people with type 2 diabetes on any anti-diabetes agents. Overall and subgroup analyses were conducted to summarise mean differences between reported glucose profiles (fasting glucose, pre-meal glucose, postprandial glucose and post-meal glucose spike/excursion) and the IDF targets. Results: Twelve observational studies totalling 731 people were included. Pooled fasting glucose (0.81 mmol/L, 95% CI, 0.53–1.09 mmol/L), postprandial glucose after breakfast (1.63 mmol/L, 95% CI, 0.79–2.48 mmol/L) and post-breakfast glucose spike (1.05 mmol/L, 95% CI, 0.13–1.96 mmol/L) were significantly higher than the IDF targets. Pre-lunch glucose, pre-dinner glucose and postprandial glucose after lunch and dinner were above the IDF targets but not significantly. Subgroup analysis showed significantly higher fasting glucose and postprandial glucose after breakfast in all groups: HbA1c
KW - continuous glucose monitoring
KW - glucose
KW - glucose profiles
KW - type 2 diabetes
U2 - 10.1016/j.diabres.2018.10.010
DO - 10.1016/j.diabres.2018.10.010
M3 - Article
VL - 146
SP - 289
EP - 299
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
ER -