Applications of ß-limit dextrin as a matrix forming excipient for fast disintegrating buccal dosage formats

Xin Qi, Richard Tester, Yu Liu, M. Mullin

Research output: Contribution to journalArticle

Abstract

The aim of this study was to compare the properties of buccal delivery matrices (wafers) made with dextrin, ß-limit dextrin and pre-gelatinised starch. The constituent a-glucans were tested for their mucoadhesive properties in solution plus their content of crystalline material (differential scanning calorimetry, DSC). Wafers were made by lyophilisation of aqueous solutions/dispersions of the a-glucans. Physical properties of the wafers were evaluated using texture analysis, dissolution coupled to photography and scanning electron microscopy (SEM).
Original languageEnglish
Article numberPMID 23331905
Pages (from-to)669-679
Number of pages11
JournalJournal of Pharmacy and Pharmaceutical Sciences
Volume15
Issue number5
Publication statusPublished - 2012

Keywords

  • dextrin
  • starch
  • scanning electron microscopy
  • wafers

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