Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats

D. Shaw, Judith Marion Annett, B. Docherty, J. C. Leslie

Research output: Contribution to journalArticle

Abstract

To establish a valid animal model of the effects of olfactory stimuli on anxiety, a series of experiments was conducted using rats in an open-field test. Throughout, effects of lavender oil were compared with the effects of chlordiazepoxide (CDP), as a reference anxiolytic with well-known effects on open-field behaviour. Rats were exposed to lavender oil (0.1–1.0 ml) for 30 min (Experiment 1) or 1 h (Experiment 2) prior to open-field test and in the open field or injected with CDP (10 mg/kg i.p.). CDP had predicted effects on behaviour, and the higher doses of lavender oil had some effects on behaviour similar to those of CDP. In Experiment 3, various combinations of pre-exposure times and amounts of lavender oil were used. With sufficient exposure time and quantity of lavender the same effects were obtained as in Experiment 2. Experiment 4 demonstrated that these behavioural effects of lavender could be obtained following pre-exposure, even if no oil was present in the open-field test. In Experiments 2–4, lavender oil increased immobility. Together, these experiments suggest that lavender oil does have anxiolytic effects in the open field, but that a sedative effect can also occur at the highest doses.

Original languageEnglish
JournalPhytomedicine
DOIs
Publication statusPublished - 1 May 2007

Fingerprint

Anti-Anxiety Agents
Inhalation
Chlordiazepoxide
Lavandula
Hypnotics and Sedatives
lavender oil
Oils
Anxiety
Animal Models

Keywords

  • anxiety
  • olfaction
  • lavender oil

Cite this

Shaw, D. ; Annett, Judith Marion ; Docherty, B. ; Leslie, J. C. / Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats. In: Phytomedicine. 2007.
@article{5beabc84d38141558d98b12ce4394f29,
title = "Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats",
abstract = "To establish a valid animal model of the effects of olfactory stimuli on anxiety, a series of experiments was conducted using rats in an open-field test. Throughout, effects of lavender oil were compared with the effects of chlordiazepoxide (CDP), as a reference anxiolytic with well-known effects on open-field behaviour. Rats were exposed to lavender oil (0.1–1.0 ml) for 30 min (Experiment 1) or 1 h (Experiment 2) prior to open-field test and in the open field or injected with CDP (10 mg/kg i.p.). CDP had predicted effects on behaviour, and the higher doses of lavender oil had some effects on behaviour similar to those of CDP. In Experiment 3, various combinations of pre-exposure times and amounts of lavender oil were used. With sufficient exposure time and quantity of lavender the same effects were obtained as in Experiment 2. Experiment 4 demonstrated that these behavioural effects of lavender could be obtained following pre-exposure, even if no oil was present in the open-field test. In Experiments 2–4, lavender oil increased immobility. Together, these experiments suggest that lavender oil does have anxiolytic effects in the open field, but that a sedative effect can also occur at the highest doses.",
keywords = "anxiety, olfaction, lavender oil",
author = "D. Shaw and Annett, {Judith Marion} and B. Docherty and Leslie, {J. C.}",
note = "Originally published in: Phytomedicine (2007), 14 (9), pp.613-620.",
year = "2007",
month = "5",
day = "1",
doi = "10.1016/j.phymed.2007.03.007",
language = "English",
journal = "Phytomedicine",
issn = "0944-7113",
publisher = "Elsevier B.V.",

}

Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats. / Shaw, D.; Annett, Judith Marion; Docherty, B.; Leslie, J. C.

In: Phytomedicine, 01.05.2007.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats

AU - Shaw, D.

AU - Annett, Judith Marion

AU - Docherty, B.

AU - Leslie, J. C.

N1 - Originally published in: Phytomedicine (2007), 14 (9), pp.613-620.

PY - 2007/5/1

Y1 - 2007/5/1

N2 - To establish a valid animal model of the effects of olfactory stimuli on anxiety, a series of experiments was conducted using rats in an open-field test. Throughout, effects of lavender oil were compared with the effects of chlordiazepoxide (CDP), as a reference anxiolytic with well-known effects on open-field behaviour. Rats were exposed to lavender oil (0.1–1.0 ml) for 30 min (Experiment 1) or 1 h (Experiment 2) prior to open-field test and in the open field or injected with CDP (10 mg/kg i.p.). CDP had predicted effects on behaviour, and the higher doses of lavender oil had some effects on behaviour similar to those of CDP. In Experiment 3, various combinations of pre-exposure times and amounts of lavender oil were used. With sufficient exposure time and quantity of lavender the same effects were obtained as in Experiment 2. Experiment 4 demonstrated that these behavioural effects of lavender could be obtained following pre-exposure, even if no oil was present in the open-field test. In Experiments 2–4, lavender oil increased immobility. Together, these experiments suggest that lavender oil does have anxiolytic effects in the open field, but that a sedative effect can also occur at the highest doses.

AB - To establish a valid animal model of the effects of olfactory stimuli on anxiety, a series of experiments was conducted using rats in an open-field test. Throughout, effects of lavender oil were compared with the effects of chlordiazepoxide (CDP), as a reference anxiolytic with well-known effects on open-field behaviour. Rats were exposed to lavender oil (0.1–1.0 ml) for 30 min (Experiment 1) or 1 h (Experiment 2) prior to open-field test and in the open field or injected with CDP (10 mg/kg i.p.). CDP had predicted effects on behaviour, and the higher doses of lavender oil had some effects on behaviour similar to those of CDP. In Experiment 3, various combinations of pre-exposure times and amounts of lavender oil were used. With sufficient exposure time and quantity of lavender the same effects were obtained as in Experiment 2. Experiment 4 demonstrated that these behavioural effects of lavender could be obtained following pre-exposure, even if no oil was present in the open-field test. In Experiments 2–4, lavender oil increased immobility. Together, these experiments suggest that lavender oil does have anxiolytic effects in the open field, but that a sedative effect can also occur at the highest doses.

KW - anxiety

KW - olfaction

KW - lavender oil

U2 - 10.1016/j.phymed.2007.03.007

DO - 10.1016/j.phymed.2007.03.007

M3 - Article

JO - Phytomedicine

JF - Phytomedicine

SN - 0944-7113

ER -