Antiviral pathway activation in patients with chronic fatigue syndrome and acute infection

John W. Gow, K. Simpson, Peter O. Behan, A. Chaudhuri, I. C. McKay, W. M.H. Behan

Research output: Contribution to journalArticle

Abstract

Gene expression of key enzymes in 2 antiviral pathways (ribonuclease latent [RNase L] and RNA-regulated protein kinase [PKR]) was compared in 22 patients with chronic fatigue syndrome (CFS), 10 patients with acute gastroenteritis, and 21 healthy volunteers. Pathway activation in the group of patients with infections differed significantly from that of the other 2 groups, in whom there was no evidence of upregulation. Therefore, assay of activation is unlikely to provide the basis for a diagnostic test for CFS.

Original languageEnglish
JournalClinical Infectious Diseases
Publication statusPublished - 1 Dec 2001

Keywords

  • acute infection
  • chronic fatigue syndrome
  • antiviral pathway activation

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