Antifungal combinations against candida albicans biofilms in vitro

Stefano P. Bachmann; Gordon Ramage; Kacy VandeWalle; Thomas F. Patterson; Brian L. Wickes; José L. López-Ribot

doi:10.1128/AAC.47.11.3657-3659.2003

Antifungal combinations against candida albicans biofilms in vitro

Stefano P. Bachmann, Gordon Ramage, Kacy VandeWalle, Thomas F. Patterson, Brian L. Wickes, José L. López-Ribot^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

Original language	English
Pages (from-to)	3657-3659
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	47
Issue number	11
DOIs	https://doi.org/10.1128/AAC.47.11.3657-3659.2003
Publication status	Published - 1 Nov 2003
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.47.11.3657-3659.2003

Cite this

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abstract = "Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.",

author = "Bachmann, {Stefano P.} and Gordon Ramage and Kacy VandeWalle and Patterson, {Thomas F.} and Wickes, {Brian L.} and L{\'o}pez-Ribot, {Jos{\'e} L.}",

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AU - Bachmann, Stefano P.

AU - Ramage, Gordon

AU - VandeWalle, Kacy

AU - Patterson, Thomas F.

AU - Wickes, Brian L.

AU - López-Ribot, José L.

PY - 2003/11/1

Y1 - 2003/11/1

N2 - Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

AB - Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

U2 - 10.1128/AAC.47.11.3657-3659.2003

DO - 10.1128/AAC.47.11.3657-3659.2003

M3 - Article

C2 - 14576141

AN - SCOPUS:0242322572

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Antifungal combinations against candida albicans biofilms in vitro

Abstract

ASJC Scopus subject areas

UN SDGs

Documents and Links

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