The ability of viridans group streptococci to bind human plasminogen and its subsequent activation into plasmin may contribute to the pathogenesis of infective endocarditis (IE) by leading to a decreased stability of the streptococcal vegetation and facilitating dehiscence of emboli. At levels greater than or equal to their MICs, penicillin, vancomycin, and linezolid are efficacious in the treatment of streptococcal endocarditis.
Teles, C., Smith, A., & Lang, S. (2012). Antibiotic modulation of the plasminogen binding ability of viridans group streptococci. Antimicrobial Agents and Chemotherapy, 56(1), 458-463. https://doi.org/10.1128/AAC.00452-11