Antibiotic modulation of the plasminogen binding ability of viridans group streptococci

Cristina Teles, Andrew Smith, Sue Lang

Research output: Contribution to journalArticle

Abstract

The ability of viridans group streptococci to bind human plasminogen and its subsequent activation into plasmin may contribute to the pathogenesis of infective endocarditis (IE) by leading to a decreased stability of the streptococcal vegetation and facilitating dehiscence of emboli. At levels greater than or equal to their MICs, penicillin, vancomycin, and linezolid are efficacious in the treatment of streptococcal endocarditis.
Original languageEnglish
Pages (from-to)458-463
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number1
Early online date28 Oct 2011
DOIs
Publication statusPublished - Jan 2012

Keywords

  • plasminogen
  • antibiotics
  • streptococci

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