Aneuploidy drives genomic instability in yeast

Jason M. Sheltzer, Heidi M. Blank, Sarah J. Pfau, Yoshie Tange, Benson M. George, Timothy J. Humpton, Ilana L. Brito, Yasushi Hiraoka, Osami Niwa, Angelika Amon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

285 Citations (Scopus)

Abstract

Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could contribute to tumorigenesis, we examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic instability. Most strains displayed increased chromosome loss and mitotic recombination, as well as defective DNA damage repair. Aneuploid fission yeast strains also exhibited defects in mitotic recombination. Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.

Original languageEnglish
Pages (from-to)1026-1030
Number of pages5
JournalScience
Volume333
Issue number6045
DOIs
Publication statusPublished - 19 Aug 2011

Keywords

  • aneuploidy
  • cellular fitness
  • cancer

ASJC Scopus subject areas

  • General

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