An update on the functional roles of long non‑coding RNAs in ischemic injury (Review)

Yanqun Cao, Jia Liu, Quzhe Lu, Kai Huang, Baolin Yang, James Reilly, Na Jiang*, Xinhua Shu, Lei Shang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)
13 Downloads (Pure)

Abstract

Ischemic injuries result from ischemia and hypoxia in cells. Tissues and organs receive an insufficient supply of nutrients and accumulate metabolic waste, which leads to the development of inflammation, fibrosis and a series of other issues. Ischemic injuries in the brain, heart, kidneys, lungs and other organs can cause severe adverse effects. Acute renal ischemia induces acute renal failure, heart ischemia induces myocardial infarction and cerebral ischemia induces cerebrovascular accidents, leading to loss of movement, consciousness and possibly, life-threatening disabilities. Existing evidence suggests that long non-coding RNAs (lncRNAs) are regulatory sequences involved in transcription, post-transcription, epigenetic regulation and multiple physiological processes. lncRNAs have been shown to be differentially expressed following ischemic injury, with the severity of the ischemic injury being affected by the upregulation or downregulation of certain types of lncRNA. The present review article provides an extensive summary of the functional roles of lncRNAs in ischemic injury, with a focus on the brain, heart, kidneys and lungs. The present review mainly summarizes the functional roles of lncRNA MALAT1, lncRNA MEG3, lncRNA H19, lncRNA TUG1, lncRNA NEAT1, lncRNA AK139328 and lncRNA CAREL, among which lncRNA MALAT1, in particular, plays a crucial role in ischemic injury and is currently a hot research topic.
Original languageEnglish
Article number91
Number of pages15
JournalInternational Journal of Molecular Medicine
Volume50
Issue number1
Early online date18 May 2022
DOIs
Publication statusPublished - Jul 2022

Keywords

  • lncRNA
  • long noncoding/genetics
  • Ischemia
  • epigenesis, genetic
  • Humans
  • brain ischemia/genetics
  • stroke/genetics
  • injury
  • miRNA
  • ischemic stroke
  • kidney transplantation
  • ischemic injury
  • RNA, long noncoding/genetics

ASJC Scopus subject areas

  • Genetics

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