An observational cross-sectional study on the corneal endothelium of medium-term rigid gas permeable contact lens wearers

Michael Doughty

Research output: Contribution to journalArticle

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Abstract

Purpose
To assess if polymegethism and pleomorphism were evident in corneal endothelium after medium-term rigid gas permeable (RGP) contact lens wear.

Methods
In a cross-sectional observational study over 12 years, single images of the central region of the corneal endothelium of one eye of 46 subjects were taken with a non-contact specular microscope, along with a measure of central corneal thickness (CCT). The images were printed onto A3-sized paper and 100 cells/image measured by planimetry.

Results
Subjects aged between 20 and 32 years, with an average cumulative RGP wear of 6.0 +/- 1.6 years (range 3–9 years) were assessed; 26 of the subjects were Caucasian and 20 were Asian. The mean CCT was 0.515 +/- 0.027 mm. The group cell area value was 401 +/- 42 sq micron to give an estimated endothelial cell density (ECD) of 2520 +/- 273 cells/sq mm. As compared to a historical database, most endothelia (37/46) showed some changes with the mean coefficient of variation on cell area (COV) being 36.7 +/- 8.0% and the percentage of 6-sided (HEX) being 51.8 +/- 8.8%. There were modest correlations between years of RGP wear and both COV (p = 0.009, r spearman = 0.424) and HEX (p = 0.025, r spearman = -0.291), but not for ECD or CCT.

Conclusions
Corneal endothelial polymegethism appears to be a commonplace consequence of RGP lens wear with the magnitude of the change being related to the cumulative duration of the lens wear.
Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalContact Lens and Anterior Eye
Volume40
Issue number2
Early online date13 Dec 2016
DOIs
Publication statusPublished - Apr 2017

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Corneal Endothelium
Contact Lenses
Cross-Sectional Studies
Gases
Lenses
Endothelial Cells
Cell Count
Endothelium
Observational Studies
Databases

Keywords

  • corneal epithelium
  • ophthalmology
  • vision sciences

Cite this

Doughty, Michael. / An observational cross-sectional study on the corneal endothelium of medium-term rigid gas permeable contact lens wearers. In: Contact Lens and Anterior Eye. 2017 ; Vol. 40, No. 2. pp. 109-115.
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abstract = "PurposeTo assess if polymegethism and pleomorphism were evident in corneal endothelium after medium-term rigid gas permeable (RGP) contact lens wear.MethodsIn a cross-sectional observational study over 12 years, single images of the central region of the corneal endothelium of one eye of 46 subjects were taken with a non-contact specular microscope, along with a measure of central corneal thickness (CCT). The images were printed onto A3-sized paper and 100 cells/image measured by planimetry.ResultsSubjects aged between 20 and 32 years, with an average cumulative RGP wear of 6.0 +/- 1.6 years (range 3–9 years) were assessed; 26 of the subjects were Caucasian and 20 were Asian. The mean CCT was 0.515 +/- 0.027 mm. The group cell area value was 401 +/- 42 sq micron to give an estimated endothelial cell density (ECD) of 2520 +/- 273 cells/sq mm. As compared to a historical database, most endothelia (37/46) showed some changes with the mean coefficient of variation on cell area (COV) being 36.7 +/- 8.0{\%} and the percentage of 6-sided (HEX) being 51.8 +/- 8.8{\%}. There were modest correlations between years of RGP wear and both COV (p = 0.009, r spearman = 0.424) and HEX (p = 0.025, r spearman = -0.291), but not for ECD or CCT.ConclusionsCorneal endothelial polymegethism appears to be a commonplace consequence of RGP lens wear with the magnitude of the change being related to the cumulative duration of the lens wear.",
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An observational cross-sectional study on the corneal endothelium of medium-term rigid gas permeable contact lens wearers. / Doughty, Michael.

In: Contact Lens and Anterior Eye, Vol. 40, No. 2, 04.2017, p. 109-115.

Research output: Contribution to journalArticle

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N1 - Record created 3 months after online pub date; validated same day for discoverability ET AAM: provided 13-3-17; 12m embargo applied Exception request email sent 20/3/17 Not exception result added by library as no response from author and has left GCU. ET 17/10/18

PY - 2017/4

Y1 - 2017/4

N2 - PurposeTo assess if polymegethism and pleomorphism were evident in corneal endothelium after medium-term rigid gas permeable (RGP) contact lens wear.MethodsIn a cross-sectional observational study over 12 years, single images of the central region of the corneal endothelium of one eye of 46 subjects were taken with a non-contact specular microscope, along with a measure of central corneal thickness (CCT). The images were printed onto A3-sized paper and 100 cells/image measured by planimetry.ResultsSubjects aged between 20 and 32 years, with an average cumulative RGP wear of 6.0 +/- 1.6 years (range 3–9 years) were assessed; 26 of the subjects were Caucasian and 20 were Asian. The mean CCT was 0.515 +/- 0.027 mm. The group cell area value was 401 +/- 42 sq micron to give an estimated endothelial cell density (ECD) of 2520 +/- 273 cells/sq mm. As compared to a historical database, most endothelia (37/46) showed some changes with the mean coefficient of variation on cell area (COV) being 36.7 +/- 8.0% and the percentage of 6-sided (HEX) being 51.8 +/- 8.8%. There were modest correlations between years of RGP wear and both COV (p = 0.009, r spearman = 0.424) and HEX (p = 0.025, r spearman = -0.291), but not for ECD or CCT.ConclusionsCorneal endothelial polymegethism appears to be a commonplace consequence of RGP lens wear with the magnitude of the change being related to the cumulative duration of the lens wear.

AB - PurposeTo assess if polymegethism and pleomorphism were evident in corneal endothelium after medium-term rigid gas permeable (RGP) contact lens wear.MethodsIn a cross-sectional observational study over 12 years, single images of the central region of the corneal endothelium of one eye of 46 subjects were taken with a non-contact specular microscope, along with a measure of central corneal thickness (CCT). The images were printed onto A3-sized paper and 100 cells/image measured by planimetry.ResultsSubjects aged between 20 and 32 years, with an average cumulative RGP wear of 6.0 +/- 1.6 years (range 3–9 years) were assessed; 26 of the subjects were Caucasian and 20 were Asian. The mean CCT was 0.515 +/- 0.027 mm. The group cell area value was 401 +/- 42 sq micron to give an estimated endothelial cell density (ECD) of 2520 +/- 273 cells/sq mm. As compared to a historical database, most endothelia (37/46) showed some changes with the mean coefficient of variation on cell area (COV) being 36.7 +/- 8.0% and the percentage of 6-sided (HEX) being 51.8 +/- 8.8%. There were modest correlations between years of RGP wear and both COV (p = 0.009, r spearman = 0.424) and HEX (p = 0.025, r spearman = -0.291), but not for ECD or CCT.ConclusionsCorneal endothelial polymegethism appears to be a commonplace consequence of RGP lens wear with the magnitude of the change being related to the cumulative duration of the lens wear.

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KW - vision sciences

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