An exploration of a varus malaligned phenotype in knee osteoarthritis

A. Dell'Isola, S.L. Smith, M.S. Andersen, M. Steultjens

Research output: Contribution to journal › Meeting abstract

Abstract

Multiple phenotypes characterised by different disease mechanisms have been hypothesised to explain the large variability in the knee osteoarthritis (KOA) population. Repeated evidence showed that varus malalignment alone is sufficient to determine disease progression in absence of other known risk factors. Therefore, the purpose of this study is: (1) to estimate the knee compression force (CF) during the stance phase of KOA patients with a varus malaligned phenotype (VMP) characterised by exclusive degeneration of the medial compartment; (2) to compare the estimated CF and other MRI biomarkers (i.e. bone marrow lesions [BML], meniscal damage) of this VMP with a group of controls (C), a group of KOA subjects with normal alignment (NA) and a group of KOA subjects with varus malalignment and cartilage degeneration that extends to the lateral compartment (VA).
Original languageEnglish
Pages (from-to)S123-S124
Number of pages2
JournalOsteoarthritis and Cartilage
Volume25
Issue numberSupplement 1
DOIs
Publication statusPublished - Apr 2017

Fingerprint

Knee Osteoarthritis
Phenotype
Cartilage
Biomarkers
Magnetic resonance imaging
Bone
Disease Progression
Knee
Bone Marrow
Control Groups
Population

Keywords

  • knee osteoarthritis
  • phenotype

Cite this

Dell'Isola, A. ; Smith, S.L. ; Andersen, M.S. ; Steultjens, M. / An exploration of a varus malaligned phenotype in knee osteoarthritis. In: Osteoarthritis and Cartilage. 2017 ; Vol. 25, No. Supplement 1. pp. S123-S124.
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title = "An exploration of a varus malaligned phenotype in knee osteoarthritis",
abstract = "Multiple phenotypes characterised by different disease mechanisms have been hypothesised to explain the large variability in the knee osteoarthritis (KOA) population. Repeated evidence showed that varus malalignment alone is sufficient to determine disease progression in absence of other known risk factors. Therefore, the purpose of this study is: (1) to estimate the knee compression force (CF) during the stance phase of KOA patients with a varus malaligned phenotype (VMP) characterised by exclusive degeneration of the medial compartment; (2) to compare the estimated CF and other MRI biomarkers (i.e. bone marrow lesions [BML], meniscal damage) of this VMP with a group of controls (C), a group of KOA subjects with normal alignment (NA) and a group of KOA subjects with varus malalignment and cartilage degeneration that extends to the lateral compartment (VA).",
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Dell'Isola, A, Smith, SL, Andersen, MS & Steultjens, M 2017, 'An exploration of a varus malaligned phenotype in knee osteoarthritis', Osteoarthritis and Cartilage, vol. 25, no. Supplement 1, pp. S123-S124. https://doi.org/10.1016/j.joca.2017.02.198

An exploration of a varus malaligned phenotype in knee osteoarthritis. / Dell'Isola, A.; Smith, S.L.; Andersen, M.S.; Steultjens, M.

In: Osteoarthritis and Cartilage, Vol. 25, No. Supplement 1, 04.2017, p. S123-S124.

Research output: Contribution to journal › Meeting abstract

TY - JOUR

T1 - An exploration of a varus malaligned phenotype in knee osteoarthritis

AU - Dell'Isola, A.

AU - Smith, S.L.

AU - Andersen, M.S.

AU - Steultjens, M.

N1 - OA

PY - 2017/4

Y1 - 2017/4

N2 - Multiple phenotypes characterised by different disease mechanisms have been hypothesised to explain the large variability in the knee osteoarthritis (KOA) population. Repeated evidence showed that varus malalignment alone is sufficient to determine disease progression in absence of other known risk factors. Therefore, the purpose of this study is: (1) to estimate the knee compression force (CF) during the stance phase of KOA patients with a varus malaligned phenotype (VMP) characterised by exclusive degeneration of the medial compartment; (2) to compare the estimated CF and other MRI biomarkers (i.e. bone marrow lesions [BML], meniscal damage) of this VMP with a group of controls (C), a group of KOA subjects with normal alignment (NA) and a group of KOA subjects with varus malalignment and cartilage degeneration that extends to the lateral compartment (VA).

AB - Multiple phenotypes characterised by different disease mechanisms have been hypothesised to explain the large variability in the knee osteoarthritis (KOA) population. Repeated evidence showed that varus malalignment alone is sufficient to determine disease progression in absence of other known risk factors. Therefore, the purpose of this study is: (1) to estimate the knee compression force (CF) during the stance phase of KOA patients with a varus malaligned phenotype (VMP) characterised by exclusive degeneration of the medial compartment; (2) to compare the estimated CF and other MRI biomarkers (i.e. bone marrow lesions [BML], meniscal damage) of this VMP with a group of controls (C), a group of KOA subjects with normal alignment (NA) and a group of KOA subjects with varus malalignment and cartilage degeneration that extends to the lateral compartment (VA).

KW - knee osteoarthritis

KW - phenotype

U2 - 10.1016/j.joca.2017.02.198

DO - 10.1016/j.joca.2017.02.198

M3 - Meeting abstract

VL - 25

SP - S123-S124

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

SN - 1063-4584

IS - Supplement 1

ER -

Dell'Isola A, Smith SL, Andersen MS, Steultjens M. An exploration of a varus malaligned phenotype in knee osteoarthritis. Osteoarthritis and Cartilage. 2017 Apr;25(Supplement 1):S123-S124. https://doi.org/10.1016/j.joca.2017.02.198

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