An expanded and flexible form of the vacuolar ATPase membrane sector

Daniel K. Clare, Elena V. Orlova, Malcolm E. Finbow, Michael A. Harrison, John B.C. Findlay, Helen R. Saibil

Research output: Contribution to journalArticle

Abstract

The vacuolar ATPase integral membrane c-ring from Nephrops norvegicus occurs in paired complexes in a double membrane. Using cryo-electron microscopy and single particle image processing of 2D crystals, we have obtained a projection structure of the c-ring of N. norvegicus. The c-ring was found to be very flexible, most likely as a result of an expanded conformation of the c subunits. This structure may support a role for the vacuolar ATPase c-rings in membrane fusion.

Original languageEnglish
JournalStructure
DOIs
Publication statusPublished - 1 Jul 2006

Keywords

  • cryo-electron microscopy
  • vacuolar ATPase

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    Clare, D. K., Orlova, E. V., Finbow, M. E., Harrison, M. A., Findlay, J. B. C., & Saibil, H. R. (2006). An expanded and flexible form of the vacuolar ATPase membrane sector. Structure. https://doi.org/10.1016/j.str.2006.05.014