An evidence based algorithm for the utility of FDG-PET for diagnosing AD according to presence of medial temporal lobe atrophy

Michael Firbank, JJ Lloyd, ED Williams, R Barber, SJ Colloby, NA Barnett, K Olsen, C Davison, Cam Donaldson, K Herholz, JT O'Brien

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Abstract

Imaging biomarkers for Alzheimer’s disease include medial temporal lobe atrophy (MTLA) depicted on CT or MRI, and patterns of reduced metabolism on FDG-PET. To investigate whether MTLA on head CT predicts the diagnostic usefulness of an additional FDG-PET scan. Participants had a clinical diagnosis of Alzheimer’s disease (AD; n=37), dementia with Lewy bodies (DLB; n=30), or were similarly aged controls (n=30). We visually rated MTLA on coronally reconstructed CT scans and, separately and blind to CT ratings, abnormal appearances on FDG-PET scans.
Original languageEnglish
Pages (from-to)491-496
Number of pages6
JournalBritish Journal of Psychiatry
Volume208
Issue number5
Early online date3 May 2016
DOIs
Publication statusPublished - May 2016

Keywords

  • Alzheimer’s disease
  • imaging biomarkers
  • temporal lobe atrophy

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    Firbank, M., Lloyd, JJ., Williams, ED., Barber, R., Colloby, SJ., Barnett, NA., Olsen, K., Davison, C., Donaldson, C., Herholz, K., & O'Brien, JT. (2016). An evidence based algorithm for the utility of FDG-PET for diagnosing AD according to presence of medial temporal lobe atrophy. British Journal of Psychiatry, 208(5), 491-496. https://doi.org/10.1192/bjp.bp.114.160804