An evidence based algorithm for the utility of FDG-PET for diagnosing AD according to presence of medial temporal lobe atrophy

Michael Firbank; JJ Lloyd; ED Williams; R Barber; SJ Colloby; NA Barnett; K Olsen; C Davison; Cam Donaldson; K Herholz; JT O'Brien

doi:10.1192/bjp.bp.114.160804

An evidence based algorithm for the utility of FDG-PET for diagnosing AD according to presence of medial temporal lobe atrophy

Michael Firbank, JJ Lloyd, ED Williams, R Barber, SJ Colloby, NA Barnett, K Olsen, C Davison, Cam Donaldson, K Herholz, JT O'Brien

Yunus Centre

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Abstract

Imaging biomarkers for Alzheimer’s disease include medial temporal lobe atrophy (MTLA) depicted on CT or MRI, and patterns of reduced metabolism on FDG-PET. To investigate whether MTLA on head CT predicts the diagnostic usefulness of an additional FDG-PET scan. Participants had a clinical diagnosis of Alzheimer’s disease (AD; n=37), dementia with Lewy bodies (DLB; n=30), or were similarly aged controls (n=30). We visually rated MTLA on coronally reconstructed CT scans and, separately and blind to CT ratings, abnormal appearances on FDG-PET scans.

Original language	English
Pages (from-to)	491-496
Number of pages	6
Journal	British Journal of Psychiatry
Volume	208
Issue number	5
Early online date	3 May 2016
DOIs	https://doi.org/10.1192/bjp.bp.114.160804
Publication status	Published - May 2016

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Keywords

Alzheimer’s disease
imaging biomarkers
temporal lobe atrophy

Cite this

Firbank, M., Lloyd, JJ., Williams, ED., Barber, R., Colloby, SJ., Barnett, NA., Olsen, K., Davison, C., Donaldson, C., Herholz, K., & O'Brien, JT. (2016). An evidence based algorithm for the utility of FDG-PET for diagnosing AD according to presence of medial temporal lobe atrophy. British Journal of Psychiatry, 208(5), 491-496. https://doi.org/10.1192/bjp.bp.114.160804

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title = "An evidence based algorithm for the utility of FDG-PET for diagnosing AD according to presence of medial temporal lobe atrophy",

abstract = "Imaging biomarkers for Alzheimer{\textquoteright}s disease include medial temporal lobe atrophy (MTLA) depicted on CT or MRI, and patterns of reduced metabolism on FDG-PET. To investigate whether MTLA on head CT predicts the diagnostic usefulness of an additional FDG-PET scan. Participants had a clinical diagnosis of Alzheimer{\textquoteright}s disease (AD; n=37), dementia with Lewy bodies (DLB; n=30), or were similarly aged controls (n=30). We visually rated MTLA on coronally reconstructed CT scans and, separately and blind to CT ratings, abnormal appearances on FDG-PET scans. ",

keywords = "Alzheimer{\textquoteright}s disease, imaging biomarkers, temporal lobe atrophy",

author = "Michael Firbank and JJ Lloyd and ED Williams and R Barber and SJ Colloby and NA Barnett and K Olsen and C Davison and Cam Donaldson and K Herholz and JT O'Brien",

note = "Accepted: December 7, 2014 (saved in SAN) Online pub: 3 May 2016; 12m embargo required AAM uploaded: 17-3-16 ET 27-6-16 Acceptance from webpage",

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Firbank, M, Lloyd, JJ, Williams, ED, Barber, R, Colloby, SJ, Barnett, NA, Olsen, K, Davison, C, Donaldson, C, Herholz, K & O'Brien, JT 2016, 'An evidence based algorithm for the utility of FDG-PET for diagnosing AD according to presence of medial temporal lobe atrophy', British Journal of Psychiatry, vol. 208, no. 5, pp. 491-496. https://doi.org/10.1192/bjp.bp.114.160804

An evidence based algorithm for the utility of FDG-PET for diagnosing AD according to presence of medial temporal lobe atrophy. / Firbank, Michael; Lloyd, JJ; Williams, ED; Barber, R; Colloby, SJ; Barnett, NA; Olsen, K; Davison, C; Donaldson, Cam; Herholz, K; O'Brien, JT.

In: British Journal of Psychiatry, Vol. 208, No. 5, 05.2016, p. 491-496.

Research output: Contribution to journal › Article

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AU - Firbank, Michael

AU - Lloyd, JJ

AU - Williams, ED

AU - Barber, R

AU - Colloby, SJ

AU - Barnett, NA

AU - Olsen, K

AU - Davison, C

AU - Donaldson, Cam

AU - Herholz, K

AU - O'Brien, JT

N1 - Accepted: December 7, 2014 (saved in SAN) Online pub: 3 May 2016; 12m embargo required AAM uploaded: 17-3-16 ET 27-6-16 Acceptance from webpage

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Documents and Links

10.1192/bjp.bp.114.160804

Firbank, M et al (2016) British Journal of Psychiatry
This is an author-produced electronic version of an article accepted for publication in the British Journal of Psychiatry. The definitive publisher-authenticated version is available online at http://bjp.rcpsych.org
Accepted author manuscript, 620 KB