Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study.
- Alzheimer's disease
- complement receptor 1 gene
- risk factor
Hamilton, G., Evans, K., MacIntyre, D., Deary, I., Dominiczak, A., Smith, B., Morris, A., Porteous, D., & Thomson, P. (2012). Alzheimer’s disease risk factor complement 1 receptor is associated with depression. Neuroscience Letters, 510(1), 6-9. https://doi.org/10.1016/j.neulet.2011.12.059