Alzheimer’s disease risk factor complement 1 receptor is associated with depression

Gillian Hamilton, Kathryn Evans, Donald MacIntyre, Ian Deary, Anna Dominiczak, Blair Smith, Andrew Morris, David Porteous, Pippa Thomson

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study.
Original languageEnglish
Pages (from-to)6-9
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - Feb 2012


  • Alzheimer's disease
  • complement receptor 1 gene
  • depression
  • risk factor


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