Alzheimer’s disease risk factor complement 1 receptor is associated with depression

Gillian Hamilton, Kathryn Evans, Donald MacIntyre, Ian Deary, Anna Dominiczak, Blair Smith, Andrew Morris, David Porteous, Pippa Thomson

Research output: Contribution to journalArticle

Abstract

Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study.
Original languageEnglish
Pages (from-to)6-9
Number of pages4
JournalNeuroscience Letters
Volume510
Issue number1
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Alzheimer's disease
  • complement receptor 1 gene
  • depression
  • risk factor

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  • Cite this

    Hamilton, G., Evans, K., MacIntyre, D., Deary, I., Dominiczak, A., Smith, B., Morris, A., Porteous, D., & Thomson, P. (2012). Alzheimer’s disease risk factor complement 1 receptor is associated with depression. Neuroscience Letters, 510(1), 6-9. https://doi.org/10.1016/j.neulet.2011.12.059