Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review

Jo Nijs, Andrea Nees, Lorna Paul, Margot De Kooning, Kelly Ickmans, Mira Meeus, Jessica Van Oosterwijck

    Research output: Contribution to journalArticle

    Abstract

    An increasing number of studies have examined how the immune system of patients with Chronic Fatigue Syndrome (CFS), or myalgic encephalomyelitis, responds to exercise. The objective of the present study was to systematically review the scientific literature addressing exercise-induced immunological changes in CFS patients compared to healthy control subjects. A systematic literature search was conducted in the PubMed and Web of science databases using different keyword combinations. We included 23 case control studies that examined whether CFS patients, compared to healthy sedentary controls, have a different immune response to exercise. The included articles were evaluated on their methodological quality. Compared to the normal response of the immune system to exercise as seen in healthy subjects, patients with CFS have a more pronounced response in the complement system (i.e. C4a split product levels), oxidative stress system (i.e. enhanced oxidative stress combined with a delayed and reduced anti-oxidant response), and an alteration in the immune cells' gene expression profile (increases in post-exercise interleukin-10 and toll-like receptor 4 gene expression), but not in circulating pro- or anti-inflammatory cytokines. Many of these immune changes relate to post-exertional malaise in CFS, a major characteristic of the illness. The literature review provides level B evidence for an altered immune response to exercise in patients with CFS.
    Original languageEnglish
    Pages (from-to)94-116
    Number of pages23
    JournalExercise Immunology Review
    Volume20
    Publication statusPublished - 2014

    Fingerprint

    Chronic Fatigue Syndrome
    Exercise
    Immune System
    Healthy Volunteers
    Oxidative Stress
    Toll-Like Receptor 4
    Transcriptome
    PubMed
    Oxidants
    Interleukin-10
    Case-Control Studies
    Anti-Inflammatory Agents
    Databases
    Cytokines
    Gene Expression

    Keywords

    • fatigue
    • pain
    • genetics
    • oxidative stress
    • complement system
    • cytokine
    • inflammation
    • exercise
    • physical activity

    Cite this

    Nijs, J., Nees, A., Paul, L., Kooning, M. D., Ickmans, K., Meeus, M., & Oosterwijck, J. V. (2014). Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review. Exercise Immunology Review, 20, 94-116.
    Nijs, Jo ; Nees, Andrea ; Paul, Lorna ; Kooning, Margot De ; Ickmans, Kelly ; Meeus, Mira ; Oosterwijck, Jessica Van. / Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review. In: Exercise Immunology Review. 2014 ; Vol. 20. pp. 94-116.
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    abstract = "An increasing number of studies have examined how the immune system of patients with Chronic Fatigue Syndrome (CFS), or myalgic encephalomyelitis, responds to exercise. The objective of the present study was to systematically review the scientific literature addressing exercise-induced immunological changes in CFS patients compared to healthy control subjects. A systematic literature search was conducted in the PubMed and Web of science databases using different keyword combinations. We included 23 case control studies that examined whether CFS patients, compared to healthy sedentary controls, have a different immune response to exercise. The included articles were evaluated on their methodological quality. Compared to the normal response of the immune system to exercise as seen in healthy subjects, patients with CFS have a more pronounced response in the complement system (i.e. C4a split product levels), oxidative stress system (i.e. enhanced oxidative stress combined with a delayed and reduced anti-oxidant response), and an alteration in the immune cells' gene expression profile (increases in post-exercise interleukin-10 and toll-like receptor 4 gene expression), but not in circulating pro- or anti-inflammatory cytokines. Many of these immune changes relate to post-exertional malaise in CFS, a major characteristic of the illness. The literature review provides level B evidence for an altered immune response to exercise in patients with CFS.",
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    Nijs, J, Nees, A, Paul, L, Kooning, MD, Ickmans, K, Meeus, M & Oosterwijck, JV 2014, 'Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review', Exercise Immunology Review, vol. 20, pp. 94-116.

    Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review. / Nijs, Jo; Nees, Andrea; Paul, Lorna; Kooning, Margot De; Ickmans, Kelly; Meeus, Mira; Oosterwijck, Jessica Van.

    In: Exercise Immunology Review, Vol. 20, 2014, p. 94-116.

    Research output: Contribution to journalArticle

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    Nijs J, Nees A, Paul L, Kooning MD, Ickmans K, Meeus M et al. Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review. Exercise Immunology Review. 2014;20:94-116.