Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes

Patrick Bell, Joy Cuthberston, Steven Patterson, Finbarr O'Harte

Research output: Contribution to journalArticle

Abstract

We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.
Original languageEnglish
Pages (from-to)68-70
Number of pages3
JournalDiabetes Research and Clinical Practice
Volume91
Issue number3
DOIs
Publication statusPublished - Mar 2011

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Keywords

  • nateglinide
  • postprandial glycaemia
  • type 2 diabetes
  • hypoglycaemia

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