We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.
- postprandial glycaemia
- type 2 diabetes
Bell, P., Cuthberston, J., Patterson, S., & O'Harte, F. (2011). Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes. Diabetes Research and Clinical Practice, 91(3), 68-70. https://doi.org/10.1016/j.diabres.2010.11.033