Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes

Patrick  Bell; Joy Cuthberston; Steven Patterson; Finbarr O'Harte

doi:10.1016/j.diabres.2010.11.033

Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes

Patrick Bell, Joy Cuthberston, Steven Patterson, Finbarr O'Harte

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.

Original language	English
Pages (from-to)	68-70
Number of pages	3
Journal	Diabetes Research and Clinical Practice
Volume	91
Issue number	3
DOIs	https://doi.org/10.1016/j.diabres.2010.11.033
Publication status	Published - Mar 2011

Keywords

nateglinide
postprandial glycaemia
type 2 diabetes
hypoglycaemia

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Documents and Links

10.1016/j.diabres.2010.11.033

Cite this

@article{d19f4ca9c0974469923362b681417151,

title = "Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes",

abstract = "We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.",

keywords = "nateglinide, postprandial glycaemia, type 2 diabetes, hypoglycaemia",

author = "Patrick Bell and Joy Cuthberston and Steven Patterson and Finbarr O'Harte",

year = "2011",

month = mar,

doi = "10.1016/j.diabres.2010.11.033",

language = "English",

volume = "91",

pages = "68--70",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes

AU - Bell, Patrick

AU - Cuthberston, Joy

AU - Patterson, Steven

AU - O'Harte, Finbarr

PY - 2011/3

Y1 - 2011/3

N2 - We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.

AB - We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.

KW - nateglinide

KW - postprandial glycaemia

KW - type 2 diabetes

KW - hypoglycaemia

U2 - 10.1016/j.diabres.2010.11.033

DO - 10.1016/j.diabres.2010.11.033

M3 - Article

SN - 0168-8227

VL - 91

SP - 68

EP - 70

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

IS - 3

ER -

Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Documents and Links

Fingerprint

Cite this