A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples

Paola Caruso; Yvonne Dempsie; Hannah Stevens; Robert A. MacDonald; Lu Long; Ruifang Lu; Kevin White; Kirsty M. Mair; Mark Southwood; Paul Upton; Mei Xin; Eva van Rooij; Eric Olson; Nicholas W. Morrell; Margaret R. MacLean; Andrew H. Baker

doi:10.1161/CIRCRESAHA.112.267591

A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples

Paola Caruso, Yvonne Dempsie, Hannah Stevens, Robert A. MacDonald, Lu Long, Ruifang Lu, Kevin White, Kirsty M. Mair, Mark Southwood, Paul Upton, Mei Xin, Eva van Rooij, Eric Olson (Editor), Nicholas W. Morrell, Margaret R. MacLean, Andrew H. Baker

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

250 Citations (Scopus)

Abstract

Despite improved understanding of the underlying genetics, pulmonary arterial hypertension (PAH) remains a severe disease. Extensive remodeling of small pulmonary arteries, including proliferation of pulmonary artery smooth muscle cells (PASMCs), characterizes PAH. MicroRNAs (miRNAs) are noncoding RNAs that have been shown to play a role in vascular remodeling.

Original language	English
Pages (from-to)	290-300
Number of pages	11
Journal	Circulation Research
Volume	111
Issue number	3
Early online date	19 Jun 2012
DOIs	https://doi.org/10.1161/CIRCRESAHA.112.267591
Publication status	Published - Jul 2012

Keywords

pulmonary arterial hypertension
PAH
vascular remodeling

Documents and Links

10.1161/CIRCRESAHA.112.267591

Cite this

Caruso, P., Dempsie, Y., Stevens, H., MacDonald, R. A., Long, L., Lu, R., White, K., Mair, K. M., Southwood, M., Upton, P., Xin, M., van Rooij, E., Olson, E. (Ed.), Morrell, N. W., MacLean, M. R., & Baker, A. H. (2012). A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples. Circulation Research, 111(3), 290-300 . https://doi.org/10.1161/CIRCRESAHA.112.267591

@article{0b3493ba96314180b3c4deaa108c2061,

title = "A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples",

abstract = "Despite improved understanding of the underlying genetics, pulmonary arterial hypertension (PAH) remains a severe disease. Extensive remodeling of small pulmonary arteries, including proliferation of pulmonary artery smooth muscle cells (PASMCs), characterizes PAH. MicroRNAs (miRNAs) are noncoding RNAs that have been shown to play a role in vascular remodeling. ",

keywords = "pulmonary arterial hypertension, PAH, vascular remodeling",

author = "Paola Caruso and Yvonne Dempsie and Hannah Stevens and MacDonald, {Robert A.} and Lu Long and Ruifang Lu and Kevin White and Mair, {Kirsty M.} and Mark Southwood and Paul Upton and Mei Xin and {van Rooij}, Eva and Eric Olson and Morrell, {Nicholas W.} and MacLean, {Margaret R.} and Baker, {Andrew H.}",

year = "2012",

month = jul,

doi = "10.1161/CIRCRESAHA.112.267591",

language = "English",

volume = "111",

pages = "290--300 ",

journal = "Circulation Research",

issn = "0009-7330",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "3",

}

Caruso, P, Dempsie, Y, Stevens, H, MacDonald, RA, Long, L, Lu, R, White, K, Mair, KM, Southwood, M, Upton, P, Xin, M, van Rooij, E, Olson, E (ed.), Morrell, NW, MacLean, MR & Baker, AH 2012, 'A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples', Circulation Research, vol. 111, no. 3, pp. 290-300 . https://doi.org/10.1161/CIRCRESAHA.112.267591

TY - JOUR

T1 - A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples

AU - Caruso, Paola

AU - Dempsie, Yvonne

AU - Stevens, Hannah

AU - MacDonald, Robert A.

AU - Long, Lu

AU - Lu, Ruifang

AU - White, Kevin

AU - Mair, Kirsty M.

AU - Southwood, Mark

AU - Upton, Paul

AU - Xin, Mei

AU - van Rooij, Eva

AU - Morrell, Nicholas W.

AU - MacLean, Margaret R.

AU - Baker, Andrew H.

A2 - Olson, Eric

PY - 2012/7

Y1 - 2012/7

N2 - Despite improved understanding of the underlying genetics, pulmonary arterial hypertension (PAH) remains a severe disease. Extensive remodeling of small pulmonary arteries, including proliferation of pulmonary artery smooth muscle cells (PASMCs), characterizes PAH. MicroRNAs (miRNAs) are noncoding RNAs that have been shown to play a role in vascular remodeling.

AB - Despite improved understanding of the underlying genetics, pulmonary arterial hypertension (PAH) remains a severe disease. Extensive remodeling of small pulmonary arteries, including proliferation of pulmonary artery smooth muscle cells (PASMCs), characterizes PAH. MicroRNAs (miRNAs) are noncoding RNAs that have been shown to play a role in vascular remodeling.

KW - pulmonary arterial hypertension

KW - PAH

KW - vascular remodeling

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84864229176&partnerID=8YFLogxK

U2 - 10.1161/CIRCRESAHA.112.267591

DO - 10.1161/CIRCRESAHA.112.267591

M3 - Article

AN - SCOPUS:84864229176

SN - 0009-7330

VL - 111

SP - 290

EP - 300

JO - Circulation Research

JF - Circulation Research

IS - 3

ER -

A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples

Abstract

Keywords

Documents and Links

Other files and links

Fingerprint

Cite this