A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples

Paola Caruso, Yvonne Dempsie, Hannah Stevens, Robert A. MacDonald, Lu Long, Ruifang Lu, Kevin White, Kirsty M. Mair, Mark Southwood, Paul Upton, Mei Xin, Eva van Rooij, Eric Olson (Editor), Nicholas W. Morrell, Margaret R. MacLean, Andrew H. Baker

Research output: Contribution to journalArticle

Abstract

Despite improved understanding of the underlying genetics, pulmonary arterial hypertension (PAH) remains a severe disease. Extensive remodeling of small pulmonary arteries, including proliferation of pulmonary artery smooth muscle cells (PASMCs), characterizes PAH. MicroRNAs (miRNAs) are noncoding RNAs that have been shown to play a role in vascular remodeling.
Original languageEnglish
Pages (from-to)290-300
Number of pages11
JournalCirculation Research
Volume111
Issue number3
Early online date19 Jun 2012
DOIs
Publication statusPublished - Jul 2012

Keywords

  • pulmonary arterial hypertension
  • PAH
  • vascular remodeling

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    Caruso, P., Dempsie, Y., Stevens, H., MacDonald, R. A., Long, L., Lu, R., White, K., Mair, K. M., Southwood, M., Upton, P., Xin, M., van Rooij, E., Olson, E. (Ed.), Morrell, N. W., MacLean, M. R., & Baker, A. H. (2012). A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples. Circulation Research, 111(3), 290-300 . https://doi.org/10.1161/CIRCRESAHA.112.267591