The skin, the largest organ of the body, is a highly complex and organised tissue comprised of a vascularised dermal layer and an avascular epidermis consisting of multiple layers of differentiated keratinocytes. As well as providing a physical barrier to environmental challenges, the epidermis is the first line of defence against invading pathogens. Central to maintenance of a healthy epidermis is a tight and highly ordered cell to cell adhesion network including adherens, desmosomes and gap junction intercellular communication channels – the epidermal junctional nexus. Connexins (Cx), gap junction proteins, are expressed throughout the epidermal layers in a complex and overlapping pattern suggesting an important role in skin homeostasis.
|Title of host publication||Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology|
|Editors||E. Ovideo-Orta , B.R. Kwak, W.H. Evans|
|Publication status||Published - 2013|
- inflammatory disorders
- immune system
Donnelly, S., Wright, C., van Steensel , M., Hodgins, M. B., & Martin, P. (2013). A role for connexins in inflammatory disorders of the epidermis. In E. Ovideo-Orta , B. R. Kwak, & W. H. Evans (Eds.), Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology CRC Press. http://www.crcpress.com/product/isbn/9781439862575