A role for connexins in inflammatory disorders of the epidermis

Steven Donnelly, Catherine Wright, Maurice van Steensel , Malcolm B. Hodgins, Patricia Martin

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

The skin, the largest organ of the body, is a highly complex and organised tissue comprised of a vascularised dermal layer and an avascular epidermis consisting of multiple layers of differentiated keratinocytes. As well as providing a physical barrier to environmental challenges, the epidermis is the first line of defence against invading pathogens. Central to maintenance of a healthy epidermis is a tight and highly ordered cell to cell adhesion network including adherens, desmosomes and gap junction intercellular communication channels – the epidermal junctional nexus. Connexins (Cx), gap junction proteins, are expressed throughout the epidermal layers in a complex and overlapping pattern suggesting an important role in skin homeostasis.
Original languageEnglish
Title of host publicationConnexin Cell Communication Channels: Roles in the Immune System and Immunopathology
EditorsE. Ovideo-Orta , B.R. Kwak, W.H. Evans
PublisherCRC Press
ISBN (Print)9781439862575
Publication statusPublished - 2013

Keywords

  • connexins
  • epidermis
  • inflammatory disorders
  • immune system

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