A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity?

A.D. Wood, K.R. Secombes, F. Thies, L.S. Aucott, A.J. Black, D.M. Reid, A. Mavroeidi, W.G. Simpson, W.D. Fraser, H.M. Macdonald

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    34 Citations (Scopus)

    Abstract

    Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D3 supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls. Introduction: This study aimed to test the supplementation effects of vitamin D3 on physical function and examine associations between overweight/obesity and the biochemical response to treatment. Methods: In a parallel group double-blind RCT, healthy postmenopausal women from North East Scotland (latitude - 57 N) aged 60-70 years (body mass index (BMI), 18-45 kg/m2) were assigned (computer randomisation) to daily vitamin D3 (400 I.U. (n = 102)/1,000 I.U. (n = 101)) or matching placebo (n = 102) (97, 96 and 100 participants analysed for outcomes, respectively) from identical coded containers for 1 year. Grip strength (primary outcome), falls, diet, physical activity and ultraviolet B radiation exposure were measured bimonthly, as were serum 25(OH)D, adjusted calcium (ACa) and phosphate. Fat/lean mass (dual energy X-ray absorptiometry), anthropometry, 1,25-dihydroxyvitamin D and parathyroid hormone were measured at baseline and 12 months. Participants and researchers were blinded throughout intervention and analysis. Results: Treatment had no effect on grip strength (mean change (SD)/year = -0.5 (2.5), -0.9 (2.7) and -0.4 (3.3) kg force for 400/1,000 I.U. vitamin D3 and placebo groups, respectively (P =.10, ANOVA)) or falls (P =.65, chi-squared test). Biochemical responses were similar across BMI categories (
    Original languageEnglish
    Pages (from-to)305-315
    Number of pages11
    JournalOsteoporosis International
    Volume25
    Issue number1
    DOIs
    Publication statusPublished - 28 Aug 2013

    Keywords

    • adiposity
    • body mass index
    • BMI
    • falls
    • grip strength
    • RCT
    • vitamin D

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