TY - JOUR
T1 - A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity?
AU - Wood, A.D.
AU - Secombes, K.R.
AU - Thies, F.
AU - Aucott, L.S.
AU - Black, A.J.
AU - Reid, D.M.
AU - Mavroeidi, A.
AU - Simpson, W.G.
AU - Fraser, W.D.
AU - Macdonald, H.M.
PY - 2013/8/28
Y1 - 2013/8/28
N2 - Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D3 supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls. Introduction: This study aimed to test the supplementation effects of vitamin D3 on physical function and examine associations between overweight/obesity and the biochemical response to treatment. Methods: In a parallel group double-blind RCT, healthy postmenopausal women from North East Scotland (latitude - 57 N) aged 60-70 years (body mass index (BMI), 18-45 kg/m2) were assigned (computer randomisation) to daily vitamin D3 (400 I.U. (n = 102)/1,000 I.U. (n = 101)) or matching placebo (n = 102) (97, 96 and 100 participants analysed for outcomes, respectively) from identical coded containers for 1 year. Grip strength (primary outcome), falls, diet, physical activity and ultraviolet B radiation exposure were measured bimonthly, as were serum 25(OH)D, adjusted calcium (ACa) and phosphate. Fat/lean mass (dual energy X-ray absorptiometry), anthropometry, 1,25-dihydroxyvitamin D and parathyroid hormone were measured at baseline and 12 months. Participants and researchers were blinded throughout intervention and analysis. Results: Treatment had no effect on grip strength (mean change (SD)/year = -0.5 (2.5), -0.9 (2.7) and -0.4 (3.3) kg force for 400/1,000 I.U. vitamin D3 and placebo groups, respectively (P =.10, ANOVA)) or falls (P =.65, chi-squared test). Biochemical responses were similar across BMI categories (
AB - Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D3 supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls. Introduction: This study aimed to test the supplementation effects of vitamin D3 on physical function and examine associations between overweight/obesity and the biochemical response to treatment. Methods: In a parallel group double-blind RCT, healthy postmenopausal women from North East Scotland (latitude - 57 N) aged 60-70 years (body mass index (BMI), 18-45 kg/m2) were assigned (computer randomisation) to daily vitamin D3 (400 I.U. (n = 102)/1,000 I.U. (n = 101)) or matching placebo (n = 102) (97, 96 and 100 participants analysed for outcomes, respectively) from identical coded containers for 1 year. Grip strength (primary outcome), falls, diet, physical activity and ultraviolet B radiation exposure were measured bimonthly, as were serum 25(OH)D, adjusted calcium (ACa) and phosphate. Fat/lean mass (dual energy X-ray absorptiometry), anthropometry, 1,25-dihydroxyvitamin D and parathyroid hormone were measured at baseline and 12 months. Participants and researchers were blinded throughout intervention and analysis. Results: Treatment had no effect on grip strength (mean change (SD)/year = -0.5 (2.5), -0.9 (2.7) and -0.4 (3.3) kg force for 400/1,000 I.U. vitamin D3 and placebo groups, respectively (P =.10, ANOVA)) or falls (P =.65, chi-squared test). Biochemical responses were similar across BMI categories (
KW - adiposity
KW - body mass index
KW - BMI
KW - falls
KW - grip strength
KW - RCT
KW - vitamin D
U2 - 10.1007/s00198-013-2473-8
DO - 10.1007/s00198-013-2473-8
M3 - Article
SN - 1433-2965
VL - 25
SP - 305
EP - 315
JO - Osteoporosis International
JF - Osteoporosis International
IS - 1
ER -