A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of ¿C gene oncogenicity

Linda Scobie; R. Hector; Louise Grant; Margaret Bell; Anne A. Neilsen; Sharon Meikle; Adrain Philbey; Adrain J. Thrasher

doi:10.1038/mt.2009.59

A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of ¿C gene oncogenicity

Linda Scobie, R. Hector, Louise Grant, Margaret Bell, Anne A. Neilsen, Sharon Meikle, Adrain Philbey, Adrain J. Thrasher

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

he emergence of leukemia following gene transfer to restore common cytokine receptor ¿ chain (¿C) function in X-linked severe combined immunodeficiency (SCID-X1) has raised important questions with respect to gene therapy safety. To explore the risk factors involved, we tested the oncogenic potential of human ¿C in new strains of transgenic mice expressing the gene under the control of the CD2 promoter and locus control region (LCR).

Original language	English
Pages (from-to)	1031-1038
Number of pages	8
Journal	Molecular Therapy
Volume	17
Issue number	6
DOIs	https://doi.org/10.1038/mt.2009.59
Publication status	Published - 1 Mar 2009

Keywords

gene therapy
leukemia
cytokine receptors

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10.1038/mt.2009.59

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title = "A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of ¿C gene oncogenicity",

abstract = "he emergence of leukemia following gene transfer to restore common cytokine receptor ¿ chain (¿C) function in X-linked severe combined immunodeficiency (SCID-X1) has raised important questions with respect to gene therapy safety. To explore the risk factors involved, we tested the oncogenic potential of human ¿C in new strains of transgenic mice expressing the gene under the control of the CD2 promoter and locus control region (LCR).",

keywords = "gene therapy, leukemia, cytokine receptors",

author = "Linda Scobie and R. Hector and Louise Grant and Margaret Bell and Neilsen, {Anne A.} and Sharon Meikle and Adrain Philbey and Thrasher, {Adrain J.}",

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A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of ¿C gene oncogenicity. / Scobie, Linda; Hector, R.; Grant, Louise; Bell, Margaret; Neilsen, Anne A.; Meikle, Sharon; Philbey, Adrain; Thrasher, Adrain J.

In: Molecular Therapy, Vol. 17, No. 6, 01.03.2009, p. 1031-1038.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of ¿C gene oncogenicity

AU - Scobie, Linda

AU - Hector, R.

AU - Grant, Louise

AU - Bell, Margaret

AU - Neilsen, Anne A.

AU - Meikle, Sharon

AU - Philbey, Adrain

AU - Thrasher, Adrain J.

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PY - 2009/3/1

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N2 - he emergence of leukemia following gene transfer to restore common cytokine receptor ¿ chain (¿C) function in X-linked severe combined immunodeficiency (SCID-X1) has raised important questions with respect to gene therapy safety. To explore the risk factors involved, we tested the oncogenic potential of human ¿C in new strains of transgenic mice expressing the gene under the control of the CD2 promoter and locus control region (LCR).

AB - he emergence of leukemia following gene transfer to restore common cytokine receptor ¿ chain (¿C) function in X-linked severe combined immunodeficiency (SCID-X1) has raised important questions with respect to gene therapy safety. To explore the risk factors involved, we tested the oncogenic potential of human ¿C in new strains of transgenic mice expressing the gene under the control of the CD2 promoter and locus control region (LCR).

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KW - leukemia

KW - cytokine receptors

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A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of ¿C gene oncogenicity

Abstract

Keywords

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