A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of ¿C gene oncogenicity

Linda Scobie, R. Hector, Louise Grant, Margaret Bell, Anne A. Neilsen, Sharon Meikle, Adrain Philbey, Adrain J. Thrasher

Research output: Contribution to journalArticle

Abstract

he emergence of leukemia following gene transfer to restore common cytokine receptor ¿ chain (¿C) function in X-linked severe combined immunodeficiency (SCID-X1) has raised important questions with respect to gene therapy safety. To explore the risk factors involved, we tested the oncogenic potential of human ¿C in new strains of transgenic mice expressing the gene under the control of the CD2 promoter and locus control region (LCR).

Original languageEnglish
Pages (from-to)1031-1038
Number of pages8
JournalMolecular Therapy
Volume17
Issue number6
DOIs
Publication statusPublished - 1 Mar 2009

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Retroviridae
Lymphoma
X-Linked Combined Immunodeficiency Diseases
Locus Control Region
Cytokine Receptors
Genetic Therapy
Transgenic Mice
Genes
Leukemia
Safety

Keywords

  • gene therapy
  • leukemia
  • cytokine receptors

Cite this

Scobie, Linda ; Hector, R. ; Grant, Louise ; Bell, Margaret ; Neilsen, Anne A. ; Meikle, Sharon ; Philbey, Adrain ; Thrasher, Adrain J. / A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of ¿C gene oncogenicity. In: Molecular Therapy. 2009 ; Vol. 17, No. 6. pp. 1031-1038.
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A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of ¿C gene oncogenicity. / Scobie, Linda; Hector, R.; Grant, Louise; Bell, Margaret; Neilsen, Anne A.; Meikle, Sharon; Philbey, Adrain; Thrasher, Adrain J.

In: Molecular Therapy, Vol. 17, No. 6, 01.03.2009, p. 1031-1038.

Research output: Contribution to journalArticle

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AU - Hector, R.

AU - Grant, Louise

AU - Bell, Margaret

AU - Neilsen, Anne A.

AU - Meikle, Sharon

AU - Philbey, Adrain

AU - Thrasher, Adrain J.

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