A cluster randomised controlled trial on the efficacy of client-centred occupational therapy in multiple sclerosis: good process, poor outcome

Isaline Eyssen, Martijn Steultjens, Vincent De Groot, Esther Steultjens, Dirk L. Knol, Chris Polman, Joost Dekker

Research output: Contribution to journalArticle


The aim of this study was to assess the efficacy of client-centred occupational therapy (OT) according to a client-centred process framework, as compared to usual care OT, in patients with multiple sclerosis (MS). A multicentre cluster randomised controlled trial with the institution (i.e. hospital or rehabilitation centre) as the unit of randomisation was performed. A total of 269 outpatients with MS, 13 hospitals and rehabilitation centres and 29 occupational therapists participated. Primary outcomes included measures of disability, participation and autonomy. Secondary outcomes included fatigue, generic health-related quality of life, quality and evaluation of therapy, therapy compliance and therapy frequency. Measurements were taken at baseline, four months and at eight months follow-up.

Original languageEnglish
Pages (from-to)1636-1646
Number of pages11
JournalDisability and Rehabilitation
Issue number19
Early online date24 Jan 2013
Publication statusPublished - Sep 2013



  • multiple sclerosis
  • occupational therapy
  • client-centred intervention

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