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  • Xinhua Shu
2020

Quantification of the influence of drugs on zebrafish larvae swimming kinematics and energetics

Zhao, Z., Li, G., Xiao, Q., Jiang, H-R., Tchivelekete, G. M., Shu, X. & Liu, H., 8 Jan 2020, In : PeerJ. 8, p. e8374 26 p.

Research output: Contribution to journalArticle

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2019

Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration

Lu, Z., Hu, X., Reilly, J., Jia, D., Liu, F., Yu, S., Liu, X., Xie, S., Qu, Z., Qin, Y., Huang, Y., Lv, Y., Li, J., Gao, P., Wong, F., Shu, X., Tang, Z. & Liu, M., 20 Sep 2019, In : Journal of Biological Chemistry. 294, 38, p. 13953-13963 11 p.

Research output: Contribution to journalArticle

Deletion of TSPO resulted in change of metabolomic profile in retinal pigment epithelial cells

Alamri, A., Biswas, L., Watson, D. G. & Shu, X., 19 Mar 2019, In : International Journal of Molecular Sciences . 20, 6

Research output: Contribution to journalArticle

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Disease mechanisms and neuroprotection by tauroursodeoxycholic acid in Rpgr knockout mice

Zhang, X., Shahani, U., Reilly, J. & Shu, X., 1 Oct 2019, In : Journal of Cellular Physiology. 234, 10, p. 18801-18812 12 p.

Research output: Contribution to journalArticle

Knockout of Nr2e3 prevents rod photoreceptor differentiation and leads to selective L-/M-cone photoreceptor degeneration in zebrafish

Xie, S., Han, S., Qu, Z., Liu, F., Li, J., Yu, S., Reilly, J., Tu, J., Liu, X., Hu, X., Yimer, T. A., Qin, Y., Huang, Y., Lv, Y., Jiang, T., Shu, X., Tang, Z. & Liu, M., 1 Jun 2019, In : Biochimica et Biophysica Acta (BBA). 1865, 6, p. 1273-1283 11 p.

Research output: Contribution to journalArticle

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Vitamin D Attenuates Oxidative Damage and Inflammation in Retinal Pigment Epithelial Cells

Tohari, A. M., Alhasani, R. H., Biswas, L., Patnaik, S. R., Reilly, J., Zeng, Z. & Shu, X., 24 Aug 2019, In : antioxidants. 8, 9, p. 341 341.

Research output: Contribution to journalArticle

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2018

Carnosic acid attenuates acrylamide-induced retinal toxicity in zebrafish embryos

Albalawi, A., Alhasani, R. H. A., Biswas, L., Reilly, J., Akhtar, S. & Shu, X., Oct 2018, In : Experimental Eye Research . 175, p. 103-114

Research output: Contribution to journalArticle

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CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1

Hu, X., Lu, Z., Yu, S., Reilly, J., Liu, F., Jia, D., Qin, Y., Han, S., Liu, X., Qu, Z., Lv, Y., Li, J., Huang, Y., Jiang, T., Jia, H., Wang, Q., Liu, J., Shu, X., Tang, Z. & Liu, M., 25 Sep 2018, In : Autophagy.

Research output: Contribution to journalArticle

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49 Downloads (Pure)

Comparative analysis of the toxicity of gold nanoparticles in zebrafish

Patibandla, S., Zhang, Y., Tohari, A. M., Gu, P., Reilly, J., Chen, Y. & Shu, X., Aug 2018, In : Journal of Applied Toxicology. 38, 8, p. 1153-1161

Research output: Contribution to journalArticle

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Gypenosides protect retinal pigment epithelium cells from oxidative stress

Alhasani, R. H., Biswas, L., Tohari, A. M., Zhou, X., Reilly, J., He, J-F. & Shu, X., Feb 2018, In : Food and Chemical Toxicology. 112, p. 76–85

Research output: Contribution to journalArticle

Open Access
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40 Downloads (Pure)

Measuring visual cortical oxygenation in diabetes using functional near-infrared spectroscopy

Aitchison, R. T., Ward, L., Kennedy, G. J., Shu, X., Mansfield, D. C. & Shahani, U., Nov 2018, In : Acta Diabetologica. 55, 11, p. 1-9 9 p.

Research output: Contribution to journalArticle

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RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry

Patnaik, S. R., Zhang, X., Biswas, L., Akhtar, S., Zhou, X., Kusuluri, D. K., Reilly, J., May-Simera, H., Chalmers, S., McCarron, J. G. & Shu, X., 1 May 2018, In : Oncotarget.

Research output: Contribution to journalArticle

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Toxicity assessment of four pharmaceuticals in aquatic environment before and after ferrate(VI) treatment

Patibandla, S., Jiang, J-Q. & Shu, X., Aug 2018, In : Journal of Environmental Chemical Engineering. 6, 4, p. 3787-3797 11 p.

Research output: Contribution to journalArticle

Open Access
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31 Downloads (Pure)
Open Access
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37 Downloads (Pure)
2017

A colour preference technique to evaluate acrylamide-induced toxicity in zebrafish

Jia, L., Raghupathy, R. K., Albalawi, A., Zhao, Z., Reilly, J., Xiao, Q. & Shu, X., Sep 2017, In : Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 199, 2017, p. 11-19

Research output: Contribution to journalArticle

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CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish

Yu, S., Li, C., Biswas, L., Hu, X., Liu, F., Reilly, J., Liu, X., Liu, Y., Huang, Y., Lu, Z., Han, S., Wang, L., Liu, J. Y., Jiang, T., Shu, X., Wong, F., Tang, Z. & Liu, M., 15 Jun 2017, In : Human Molecular Genetics. 26, 12, p. 2335-2345 11 p.

Research output: Contribution to journalArticle

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Coenzyme Q10 as a potential therapeutic candidate for treating inherited photoreceptor degeneration

Zhang, X., Biswas, L., Tohari, A. M., Reilly, J., Tiano, L. & Shu, X., 31 Dec 2017, In : Neural Regeneration Research. 12, p. 1979-1981 5 p.

Research output: Contribution to journalArticle

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Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish

Liu, F., Xiao, Q., Yu, S., Soares, D. C., Yang, L., Weng, J., Li, C., Gao, M., Lu, Z., Hu, X., Liu, X., Jiang, T., Liu, J. Y., Shu, X., Tang, Z. & Liu, M., Apr 2017, In : Journal of Biological Chemistry. 292, p. 6225-6239 15 p.

Research output: Contribution to journalArticle

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Protective effect of carnosic acid against acrylamide-induced toxicity in RPE cells

Albalawi, A. E. S., Alhasani, R. H. A., Biswas, L., Reilly, J. & Shu, X., Oct 2017, In : Food and Chemical Toxicology. 108, Part B, p. 543-553 11 p.

Research output: Contribution to journalArticle

Open Access
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32 Downloads (Pure)
Open Access
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56 Downloads (Pure)

Rpgrip1 is required for rod outer segment development and ciliary protein trafficking in zebrafish

Raghupathy, R. K., Zhang, X., Liu, F., Alhasani, R. H., Biswas, L., Akhtar, S., Pan, L., Moens, C. B., Li, W., Liu, M., Kennedy, B. N. & Shu, X., 4 Dec 2017, In : Scientific Reports. 7, 14 p., 16881.

Research output: Contribution to journalArticle

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Therapeutic potential of co-enzyme Q10 in retinal diseases

Zhang, X., Tohari, A. M., Marcheggiani, F., Zhou, X., Reilly, J., Tiano, L. & Shu, X., 2017, In : Current Medicinal Chemistry. 24, 39, p. 4329-4339 11 p.

Research output: Contribution to journalArticle

Open Access
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69 Downloads (Pure)
2016

Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish

Raghupathy, R. K., Zhang, X., Alhasani, R. H., Zhou, X., Mullen, M., Reilly, J., Li, W., Liu, M. & Shu, X., Aug 2016, In : Cell Biochemistry and Function. 34, 6, p. 429–440 12 p.

Research output: Contribution to journalArticle

Open Access
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Isolation and Identification of Cellulose-Degradation Bacteria from Cattle Slurry

Alharbi, R. M. S., Pahl, O., Shu, X. & Hunter, C., 4 Sep 2016.

Research output: Contribution to conferencePoster

Protection against oxidative stress by vitamin D in cone cells

Tohari, A. M., Zhou, X. & Shu, X., Mar 2016, In : Cell Biochemistry and Function. 34, 2, p. 82-94 13 p.

Research output: Contribution to journalArticle

Reflection on the efficacy of gene therapy in the treatment of inherited retinal degeneration

Zhang, X., Reilly, J. & Shu, X., 10 Feb 2016, In : Cloning and Transgenesis. 5, 1, p. e122 1 p.

Research output: Contribution to journalArticle

2015

Evolutionary characterization of the retinitis pigmentosa GTPase regulator gene

Raghupathy, R. K., Gautier, P., Soares, D. C., Wright, A. F. & Shu, X., Oct 2015, In : Investigative Ophthalmology and Visual Science. 56, 11, p. 6255-6264 10 p.

Research output: Contribution to journalArticle

Histological characterization of the Dicer1 mutant zebrafish retina

Akhtar, S., Patnaik, S. R., Raghupathy, R. K., Al-Mubrab, T. M., Craft, J. A. & Shu, X., 1 Jun 2015, In : Journal of Ophthalmology. 2015, 3, 8 p., 309510.

Research output: Contribution to journalArticle

Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish

Liu, F., Chen, J., Yu, S., Raghupathy, R. K., Liu, X., Qin, Y., Li, C., Huang, M., Liao, S., Wang, J., Zou, J., Shu, X., Tang, Z. & Liu, M., 15 Aug 2015, In : Human Molecular Genetics. 24, 16, p. 4648-4659 12 p.

Research output: Contribution to journalArticle

MicroRNA-sequence profiling reveals novel osmoregulatory microRNA expression patterns in catadromous eel anguilla marmorata

Wang, X., Yin, D., Wei, P., Yin, S., Wang, L., Jia, Y. & Shu, X., 24 Aug 2015, In : PLoS ONE . 20 p.

Research output: Contribution to journalArticle

Open Access
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Pharmaceuticals in sewage systems and surface waters: status quo

Breure, A. M., Casellas, M., Craft, J., Dagot, C., Frew, R. G., Helwig, K. P. M., Hunter, C., Klepiszewski, K., Lachassagne, D., Levi, Y., Lyko, S., MacLachlan, J., McNaughtan, M., Nafo, I., Roberts, J. B., Wiest, C., Perrodin, Y., Ploy, M. C., Shu, X. & Stalder, T., Jun 2015, No pills in waters : noPILLS report: Interreg IV B NWE project partnership 2012-2015. Essen, p. 24-41 17 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photoreceptor rescue by an abbreviated human RPGR gene in a murine model of X-linked retinitis pigmentosa

Pawlyk, B. S., Bulgakov, O., Sun, X., Adamian, M., Shu, X., Smith, A. J., Berson, E. L., Ali, R. R., Khani, S., Wright, A. F., Sandberg, M. A. & Li, T., Sep 2015, In : Gene Therapy. 23, 2, p. 196-204 9 p.

Research output: Contribution to journalArticle

Retinitis pigmentosa: disease mechanisms, diagnosis, and therapies

Shu, X., Pang, J., Zhang, H. & Mansfield, D., 2015, In : Journal of Ophthalmology. 2015, 1 p., 819452.

Research output: Contribution to journalEditorial

The role of RPGR and its interacting proteins in ciliopathies

Patnaik, S. R., Raghupathy, R. K., Zhang, X., Mansfield, D. & Shu, X., 2015, In : Journal of Ophthalmology. 2015, 10 p., 414781.

Research output: Contribution to journalArticle

2014

CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis

Lia, C., Wang, L., Zhang, J., Huang, M., Wong, F., Liu, X., Liu, F., Cui, X., Yang, G., Chen, J., Liu, Y., Wang, J., Liao, S., Gao, M., Hu, X., Shu, X., Wang, Q., Yin, Z., Tang, Z. & Liu, M., Jul 2014, In : Biochimica et Biophysica Acta (BBA). 1842, 7, p. 1121-1129 9 p.

Research output: Contribution to journalArticle

Pathogenesis of X-linked RP3: insights from animal models

Raghupathy, R. K., McCulloch, D. L., Akhtar, S., Al-Mubrad, T. M. & Shu, X., 25 Mar 2014, In : Advances in Experimental Medicine and Biology. 801, p. 477-485 9 p.

Research output: Contribution to journalArticle

2013

Gene therapy for x-linked retinitis pigmentosa

Shu, X., 25 Dec 2013, In : Cloning and Transgenesis. 3, 1, p. e108 2 p.

Research output: Contribution to journalEditorial

Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration

Ansari, M., Mckeigue, P. M., Skerka, C., Hayward, C., Rudan, I., Vitart, V., Polasek, O., Armbrecht, A-M., Yates, J. R. W., Vatavuk, Z., Bencic, G., Kolcic, I., Oostra, B. A., Van Duijn, C. M., Campbell, S., Stanton, C. M., Huffman, J., Shu, X., Khan, J. C., Shahid, H. & 11 others, Harding, S. P., Bishop, P. N., Deary, I. J., Moore, A. T., Dhillon, B., Rudan, P., Zipfel, P. F., Sim, R. B., Hastie, N. D., Campbell, H. & Wright, A. F., 19 Jul 2013, In : Human Molecular Genetics. 22, 23, p. 4857-4869 13 p.

Research output: Contribution to journalArticle

Transgenic zebrafish models for understanding retinitis pigmentosa

Raghupathy, R. K., Patnaik, S. R. & Shu, X., 7 Aug 2013, In : Cloning and Transgenesis. 2, 2, 5 p.

Research output: Contribution to journalArticle

Zebrafish model for the genetic basis of X-linked retinitis pigmentosa

Raghupathy, R. K., McCulloch, D., Akhtar, S., Al-mubrad, T. M. & Shu, X., Mar 2013, In : Zebrafish. 10, 1, p. 62-69 8 p.

Research output: Contribution to journalArticle

2012

Functional characterization of the human RPGR proximal promoter

Shu, X., Simpson, J. R., Hart, A. W., Zeng, Z., Patnaik, S. R., Gautier, P., Murdoch, E., Tulloch, B. & Wright, A. F., Jun 2012, In : Investigative Ophthalmology & Visual Science. 53, 7, p. 3951-3958 8 p.

Research output: Contribution to journalArticle

Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept

Dinculescu, A., Estreicher, J., Zenteno, J. C., Aleman, T. S., Schwartz, S. B., Huang, W. C., Roman, A. J., Sumaroka, A., Li, Q., Deng, W-T., Min, S-H., Chiodo, V. A., Neeley, A., Liu, X., Shu, X., Matias-Florentino, M., Buentello-Volante, B., Boye, S. L., Cideciyan, A. V., Hauswirth, W. W. & 1 others, Jacobson, S. G., Apr 2012, In : Human Gene Therapy. 23, 4, p. 367-376 10 p.

Research output: Contribution to journalArticle

2011

Characterisation of C1qtnf5 Ser163Arg knock-in mouse model of late-onset retinal macular degeneration

Shu, X., Luhmann, U. F. O., Aleman, T. S., Barker, S. E., Lennon, A., Tulloch, B., Chen, M., Xu, H., Jacobson, S. G., Ali, R. & Wright, A. F., 16 Nov 2011, In : PLoS ONE . 6, p. e27433

Research output: Contribution to journalArticle

Evidence of severe mitochondrial oxidative stress and a protective effect of low oxygen in mouse models of inherited photoreceptor degeneration

Vlachantoni, D., Bramall, A. N., Murphy, M. P., Taylor, R. W., Shu, X., Tulloch, B., Van Veen, T. & Turnbull, D. M., 1 Jan 2011, In : Human Molecular Genetics. 20, 2, p. 322-335 14 p.

Research output: Contribution to journalArticle

Knockdown of the zebrafish ortholog of the retinitis pigmentosa 2 (RP2) gene results in retinal degeneration

Shu, X., Zeng, Z., Gautier, P., Lennon, A., Gakovic, M., Cheetham, M. E., Patton, E. E. & Wright, A. F., 1 May 2011, In : Investigative Ophthalmology and Visual Science. 52, 6, p. 2960-2966 7 p.

Research output: Contribution to journalArticle

The role of RPGR in cilia formation and actin stability

Gakovic, M., Shu, X., Kasioulis, I., Carpanini, S., Moraga, I. & Wright, A. F., 2011, In : Human Molecular Genetics. 20, 24, p. 4840-4850 11 p.

Research output: Contribution to journalArticle

Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2

Dinour, D., Gray, N. K., Gannon, L., Knox, A. J. S., Shalev, H., Sela, B-A., Campbell, S., Sawyer, L., Shu, X., Valsamidou, E., Landau, D., Wright, A. F. & Holtzman, E. J., 2 Aug 2011, In : Nephrology Dialysis Transplantation. 27, 3, p. 1035-1041 7 p.

Research output: Contribution to journalArticle