Project Details
Description
To determine whether CYTSB is altered pre-symptomatically in SMA, I plan to investigate CYTSB expression in a range of mouse tissues obtained from both pre-symptomatic and post-symptomatic SMA models. Tissue from animal models is already banked, with the methodology optimised and some quantification carried out.
b) To determine whether CYTSB interacts with actin, the dynamics of which is known to be significantly altered in SMA, consumables have mostly been purchased and optimisation of co-immunoprecipitation experiments using HEK293 cells has begun
b) To determine whether CYTSB interacts with actin, the dynamics of which is known to be significantly altered in SMA, consumables have mostly been purchased and optimisation of co-immunoprecipitation experiments using HEK293 cells has begun
Short title | CYTSB in SMA |
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Status | Not started |
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
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