The role of CYTSB in spinal muscular atrophy

Project Details


To determine whether CYTSB is altered pre-symptomatically in SMA, I plan to investigate CYTSB expression in a range of mouse tissues obtained from both pre-symptomatic and post-symptomatic SMA models. Tissue from animal models is already banked, with the methodology optimised and some quantification carried out.
b) To determine whether CYTSB interacts with actin, the dynamics of which is known to be significantly altered in SMA, consumables have mostly been purchased and optimisation of co-immunoprecipitation experiments using HEK293 cells has begun
Short titleCYTSB in SMA
StatusNot started

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.